A Direct Comparison of the Relationship of Epigenetic Aging and Epigenetic Substance Consumption Markers to Mortality in the Framingham Heart Study.
DNA methylation
alcohol
aryl hydrocarbon receptor repressor
epigenetic aging
smoking
survival
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
15 01 2019
15 01 2019
Historique:
received:
10
12
2018
revised:
08
01
2019
accepted:
10
01
2019
entrez:
18
1
2019
pubmed:
18
1
2019
medline:
18
1
2019
Statut:
epublish
Résumé
A number of studies have examined the relationship of indices of epigenetic aging (EA) to key health outcomes. Unfortunately, our understanding of the relationship of EA to mortality and substance use-related health variables is unclear. In order to clarify these interpretations, we analyzed the relationship of the Levine EA index (LEA), as well as established epigenetic indices of cigarette (cg05575921) and alcohol consumption (cg04987734), to all-cause mortality in the Framingham Heart Study Offspring Cohort (
Identifiants
pubmed: 30650672
pii: genes10010051
doi: 10.3390/genes10010051
pmc: PMC6356614
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAAA NIH HHS
ID : R44 AA022041
Pays : United States
Organisme : NCI NIH HHS
ID : R44 CA213507
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA037648
Pays : United States
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