PI3Kγ (Phosphoinositide 3-Kinase γ) Regulates Vascular Smooth Muscle Cell Phenotypic Modulation and Neointimal Formation Through CREB (Cyclic AMP-Response Element Binding Protein)/YAP (Yes-Associated Protein) Signaling.

Adaptor Proteins, Signal Transducing / physiology Animals Carotid Artery, Common Cell Cycle Proteins / physiology Cell Movement Cells, Cultured Class Ib Phosphatidylinositol 3-Kinase / deficiency Cyclic AMP Response Element-Binding Protein / physiology Gene Expression Regulation Gene Knockdown Techniques Ligation Male Mice Mice, Inbred C57BL Muscle, Smooth, Vascular / pathology Myocytes, Smooth Muscle / enzymology Neointima / physiopathology Phenotype RNA Interference RNA, Small Interfering / genetics Radiation Chimera Signal Transduction / physiology Vascular Remodeling YAP-Signaling Proteins
bone marrow carotid arteries cell proliferation cyclic AMP response element binding protein muscle cells

Journal

Arteriosclerosis, thrombosis, and vascular biology
ISSN: 1524-4636
Titre abrégé: Arterioscler Thromb Vasc Biol
Pays: United States
ID NLM: 9505803

Informations de publication

Date de publication:
03 2019
Historique:
pubmed: 18 1 2019
medline: 14 1 2020
entrez: 18 1 2019
Statut: ppublish

Résumé

Objective- Vascular smooth muscle cells (VSMCs) phenotype modulation is critical for the resolution of vascular injury. Genetic and pharmacological inhibition of PI3Kγ (phosphoinositide 3-kinase γ) exerts anti-inflammatory and protective effects in multiple cardiovascular diseases. This study investigated the role of PI3Kγ and its downstream effector molecules in the regulation of VSMC phenotypic modulation and neointimal formation in response to vascular injury. Approach and Results- Increased expression of PI3Kγ was found in injured vessel wall as well in cultured, serum-activated wild-type VSMCs, accompanied by a reduction in the expression of calponin and SM22α, 2 differentiation markers of VSMCs. However, the injury-induced downregulation of calponin and SM22α was profoundly attenuated in PI3Kγ

Identifiants

DOI: 10.1161/ATVBAHA.118.312212 PMID: 30651001 PMC: PMC6393180
pubmed: 30651001
doi: 10.1161/ATVBAHA.118.312212
pmc: PMC6393180
mid: NIHMS1517934
doi:

Substances chimiques

Adaptor Proteins, Signal Transducing 0
Cell Cycle Proteins 0
Creb1 protein, mouse 0
Cyclic AMP Response Element-Binding Protein 0
RNA, Small Interfering 0
YAP-Signaling Proteins 0
Yap1 protein, mouse 0
Class Ib Phosphatidylinositol 3-Kinase EC 2.7.1.137
Pik3cg protein, mouse EC 2.7.1.153

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e91-e105

Subventions

Organisme : NINDS NIH HHS
ID : R01 NS089991
Pays : United States

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Auteurs

Qihong Yu (Q)

From the Department of Hepatobiliary Surgery (Q.Y., D.X., X.Z., X.C., S.H., M.L., Q.Z., Z.S.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Wei Li (W)

Departments of Gerontology (W.L.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Rong Jin (R)

Department of Neurosurgery, Louisiana State University Health Sciences Center, Shreveport (R.J., S.Y., G.L.).
and Department of Neurosurgery, Penn State Hershey Medical Center, Hershey, PA (R.J., W.Z., G.L.).

Shiyong Yu (S)

Department of Neurosurgery, Louisiana State University Health Sciences Center, Shreveport (R.J., S.Y., G.L.).
Department of Cardiology, Xinqiao Hospital, Third Military Medical University, Chongqing, China (S.Y.).

Dawei Xie (D)

From the Department of Hepatobiliary Surgery (Q.Y., D.X., X.Z., X.C., S.H., M.L., Q.Z., Z.S.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Xichuan Zheng (X)

From the Department of Hepatobiliary Surgery (Q.Y., D.X., X.Z., X.C., S.H., M.L., Q.Z., Z.S.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Wei Zhong (W)

and Department of Neurosurgery, Penn State Hershey Medical Center, Hershey, PA (R.J., W.Z., G.L.).

Xiang Cheng (X)

From the Department of Hepatobiliary Surgery (Q.Y., D.X., X.Z., X.C., S.H., M.L., Q.Z., Z.S.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Shaobo Hu (S)

From the Department of Hepatobiliary Surgery (Q.Y., D.X., X.Z., X.C., S.H., M.L., Q.Z., Z.S.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Min Li (M)

From the Department of Hepatobiliary Surgery (Q.Y., D.X., X.Z., X.C., S.H., M.L., Q.Z., Z.S.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Qichang Zheng (Q)

From the Department of Hepatobiliary Surgery (Q.Y., D.X., X.Z., X.C., S.H., M.L., Q.Z., Z.S.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Guohong Li (G)

Department of Neurosurgery, Louisiana State University Health Sciences Center, Shreveport (R.J., S.Y., G.L.).
and Department of Neurosurgery, Penn State Hershey Medical Center, Hershey, PA (R.J., W.Z., G.L.).

Zifang Song (Z)

From the Department of Hepatobiliary Surgery (Q.Y., D.X., X.Z., X.C., S.H., M.L., Q.Z., Z.S.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines adaptatrices de la transduction du signal › PI3Kγ (Phosphoinositide 3-Kinase γ) Regulates...
questionsmedicales.fr › Eucaryotes › Animaux › PI3Kγ (Phosphoinositide 3-Kinase γ) Regulates...
questionsmedicales.fr › Système cardiovasculaire › Vaisseaux sanguins › Artères › Artères carotides › Artère carotide commune › PI3Kγ (Phosphoinositide 3-Kinase γ) Regulates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cycle cellulaire › PI3Kγ (Phosphoinositide 3-Kinase γ) Regulates...
questionsmedicales.fr › Phénomènes physiologiques › Mouvement cellulaire › PI3Kγ (Phosphoinositide 3-Kinase γ) Regulates...
questionsmedicales.fr › Cellules › Cellules cultivées › PI3Kγ (Phosphoinositide 3-Kinase γ) Regulates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Phosphatidylinositol 3-kinases › Phosphatidylinositol-4-phosphate 3-kinase › Phosphatidylinositol 3-kinases de classe I › Phosphatidylinositol 3-kinases de classe Ib › PI3Kγ (Phosphoinositide 3-Kinase γ) Regulates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique et à glissière à leucines › Protéine de liaison à l'élément de réponse à l'AMP cyclique › PI3Kγ (Phosphoinositide 3-Kinase γ) Regulates...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › PI3Kγ (Phosphoinositide 3-Kinase γ) Regulates...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Ciblage de gène › Techniques de knock-down de gènes › PI3Kγ (Phosphoinositide 3-Kinase γ) Regulates...
questionsmedicales.fr › Procédures de chirurgie opératoire › Ligature › PI3Kγ (Phosphoinositide 3-Kinase γ) Regulates...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › PI3Kγ (Phosphoinositide 3-Kinase γ) Regulates...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › PI3Kγ (Phosphoinositide 3-Kinase γ) Regulates...
questionsmedicales.fr › Tissus › Muscles › Muscles lisses › Muscles lisses vasculaires › PI3Kγ (Phosphoinositide 3-Kinase γ) Regulates...
questionsmedicales.fr › Cellules › Cellules musculaires › Myocytes du muscle lisse › PI3Kγ (Phosphoinositide 3-Kinase γ) Regulates...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Néointima › PI3Kγ (Phosphoinositide 3-Kinase γ) Regulates...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › PI3Kγ (Phosphoinositide 3-Kinase γ) Regulates...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Extinction de l'expression des gènes › Interférence par ARN › PI3Kγ (Phosphoinositide 3-Kinase γ) Regulates...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › Petit ARN interférent › PI3Kγ (Phosphoinositide 3-Kinase γ) Regulates...
questionsmedicales.fr › Phénomènes du système immunitaire › Sujet immunodéprimé › Chimère post-radique › PI3Kγ (Phosphoinositide 3-Kinase γ) Regulates...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › PI3Kγ (Phosphoinositide 3-Kinase γ) Regulates...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Remodelage vasculaire › PI3Kγ (Phosphoinositide 3-Kinase γ) Regulates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines adaptatrices de la transduction du signal › Protéines de signalisation YAP › PI3Kγ (Phosphoinositide 3-Kinase γ) Regulates...