Expression of CUEDC2 in colorectal cancer with different invasion and migration abilities.
Adaptor Proteins, Signal Transducing
Adolescent
Adult
Aged
Biomarkers, Tumor
/ genetics
Carrier Proteins
/ genetics
Cell Movement
Cell Proliferation
Colorectal Neoplasms
/ genetics
Female
Gene Expression Regulation, Neoplastic
Humans
Male
Membrane Proteins
/ genetics
Middle Aged
Neoplasm Invasiveness
Prognosis
RNA, Messenger
Tumor Cells, Cultured
Young Adult
CUEDC2
Colorectal cancer
cell line
invasion and migration
Journal
The Journal of international medical research
ISSN: 1473-2300
Titre abrégé: J Int Med Res
Pays: England
ID NLM: 0346411
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
pubmed:
18
1
2019
medline:
14
6
2019
entrez:
18
1
2019
Statut:
ppublish
Résumé
To investigate CUE domain containing 2 ( CUEDC2) expression in colorectal cancer with different invasion and migration abilities. Fresh colon cancer tissues, obtained from patients with or without lymph node metastasis who were treated at the Department of General Surgery, Chinese People's Liberation Army General Hospital, and SW620 and HT29 colorectal cancer cell lines, were analysed for CUEDC2 expression. Real-time polymerase chain reaction showed significantly higher CUEDC2 mRNA levels in colon cancer tissue from patients with ( n = 8) versus without ( n = 8) lymph node metastasis, and in SW620 versus HT29 cells. Western blots revealed significantly higher CUEDC2 protein levels in colon cancer tissues from patients with versus without lymph node metastasis, and in SW620 versus HT29 cells. Colorectal cancer tissues from patients with lymph node metastasis showed more intense immunohistochemical staining and moderate staining of cell nuclei and cytoplasm versus less intense/weak staining in tissues from patients without lymph node metastasis. CUEDC2 is highly expressed in colorectal cancer tissues and colorectal cancer cell lines with high invasion and migration ability. CUEDC2 may be involved in promoting invasion and metastasis in colorectal cancer.
Identifiants
pubmed: 30651016
doi: 10.1177/0300060518813072
pmc: PMC6381460
doi:
Substances chimiques
Adaptor Proteins, Signal Transducing
0
Biomarkers, Tumor
0
CUEDC2 protein, human
0
Carrier Proteins
0
Membrane Proteins
0
RNA, Messenger
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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