Measurement of Tumor Antioxidant Capacity and Prediction of Chemotherapy Resistance in Preclinical Models of Ovarian Cancer by Positron Emission Tomography.
Animals
Antineoplastic Agents
/ pharmacology
Antioxidants
/ metabolism
Biomarkers
Cell Line, Tumor
Cystine
/ metabolism
Disease Models, Animal
Drug Resistance, Neoplasm
Female
Humans
Mice
Models, Biological
Neoplasm Grading
Ovarian Neoplasms
/ diagnosis
Positron Emission Tomography Computed Tomography
Positron-Emission Tomography
/ methods
Radiopharmaceuticals
Reactive Oxygen Species
/ metabolism
Xenograft Model Antitumor Assays
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
ISSN: 1557-3265
Titre abrégé: Clin Cancer Res
Pays: United States
ID NLM: 9502500
Informations de publication
Date de publication:
15 04 2019
15 04 2019
Historique:
received:
19
10
2018
revised:
18
12
2018
accepted:
14
01
2019
pubmed:
18
1
2019
medline:
30
5
2020
entrez:
18
1
2019
Statut:
ppublish
Résumé
Drug resistance is a major obstacle for the effective treatment of patients with high-grade serous ovarian cancer (HGSOC). Currently, there is no satisfactory way to identify patients with HGSOC that are refractive to the standard of care. Here, we propose the system x Using matched chemotherapy sensitive and resistant ovarian cancer cell lines, we assessed their antioxidant capacity and its relation to [ High intracellular glutathione (GSH) and low reactive oxygen species corresponded to decreased [ This study demonstrates the ability of [
Identifiants
pubmed: 30651275
pii: 1078-0432.CCR-18-3423
doi: 10.1158/1078-0432.CCR-18-3423
pmc: PMC6522377
mid: EMS81519
doi:
Substances chimiques
Antineoplastic Agents
0
Antioxidants
0
Biomarkers
0
Radiopharmaceuticals
0
Reactive Oxygen Species
0
Cystine
48TCX9A1VT
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2471-2482Subventions
Organisme : Cancer Research UK
ID : C53309/A19702
Pays : United Kingdom
Organisme : Cancer Research UK
ID : A16463
Pays : United Kingdom
Organisme : Department of Health
Pays : United Kingdom
Organisme : Cancer Research UK
ID : A18088
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 107610
Pays : United Kingdom
Informations de copyright
©2019 American Association for Cancer Research.
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