Genistein Prevents Development of Spontaneous Ovarian Cancer and Inhibits Tumor Growth in Hen Model.
Adenocarcinoma, Mucinous
/ metabolism
Animals
Anticarcinogenic Agents
/ pharmacology
Cell Transformation, Neoplastic
/ drug effects
Chickens
Cystadenocarcinoma, Serous
/ metabolism
Disease Models, Animal
Female
Gene Expression Regulation, Neoplastic
/ drug effects
Genistein
/ pharmacology
Ovarian Neoplasms
/ metabolism
Journal
Cancer prevention research (Philadelphia, Pa.)
ISSN: 1940-6215
Titre abrégé: Cancer Prev Res (Phila)
Pays: United States
ID NLM: 101479409
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
08
09
2017
revised:
30
07
2018
accepted:
10
01
2019
pubmed:
18
1
2019
medline:
10
6
2020
entrez:
18
1
2019
Statut:
ppublish
Résumé
Genistein, the major isoflavone in soybean, has been reported to exert anticancer effects on various types of cancer including ovarian cancer; however, its chemopreventive effects and mechanisms of action in ovarian cancer have not been fully elucidated in spontaneously developing ovarian cancer models. In this study, we demonstrated the preventive effects and mechanisms of genistein in the laying hen model that develops spontaneous ovarian cancer at high incidence rates. Laying hens were randomized to three groups: control (3.01 mg/hen,
Identifiants
pubmed: 30651293
pii: 1940-6207.CAPR-17-0289
doi: 10.1158/1940-6207.CAPR-17-0289
doi:
Substances chimiques
Anticarcinogenic Agents
0
Genistein
DH2M523P0H
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
135-146Informations de copyright
©2019 American Association for Cancer Research.