Hippo signaling promotes lung epithelial lineage commitment by curbing Fgf10 and β-catenin signaling.

Adaptor Proteins, Signal Transducing / metabolism Animals Cell Cycle Proteins Cell Differentiation Cell Lineage Cytoplasm / metabolism Epithelial Cells / cytology Female Fibroblast Growth Factor 10 / metabolism Hippo Signaling Pathway Lung / cytology Male Mice Models, Biological Organogenesis Phenotype Phosphoproteins / metabolism Protein Serine-Threonine Kinases / metabolism Pulmonary Alveoli / embryology Signal Transduction Trans-Activators YAP-Signaling Proteins beta Catenin / metabolism
Differentiation Fgf10 Fgfr2 Hippo Ilk Integrin Lung Progenitor Yap β-Catenin

Journal

Development (Cambridge, England)
ISSN: 1477-9129
Titre abrégé: Development
Pays: England
ID NLM: 8701744

Informations de publication

Date de publication:
16 01 2019
Historique:
received: 13 08 2018
accepted: 07 12 2018
entrez: 18 1 2019
pubmed: 18 1 2019
medline: 10 9 2019
Statut: epublish

Résumé

Organ growth and tissue homeostasis rely on the proliferation and differentiation of progenitor cell populations. In the developing lung, localized

Identifiants

DOI: 10.1242/dev.166454 PMID: 30651296 PMC: PMC6361136
pubmed: 30651296
pii: 146/2/dev166454
doi: 10.1242/dev.166454
pmc: PMC6361136
pii:
doi:

Substances chimiques

Adaptor Proteins, Signal Transducing 0
Cell Cycle Proteins 0
Fgf10 protein, mouse 0
Fibroblast Growth Factor 10 0
Phosphoproteins 0
Trans-Activators 0
Wwtr1 protein, mouse 0
YAP-Signaling Proteins 0
Yap1 protein, mouse 0
beta Catenin 0
integrin-linked kinase EC 2.7.1.-
Protein Serine-Threonine Kinases EC 2.7.11.1

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NCI NIH HHS
ID : P30 CA013148
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL126732
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL132156
Pays : United States

Informations de copyright

© 2019. Published by The Company of Biologists Ltd.

Déclaration de conflit d'intérêts

Competing interestsThe authors declare no competing or financial interests.

Références

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Auteurs

Thomas Volckaert (T)

Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, AL 35294, USA.

Tingting Yuan (T)

Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, AL 35294, USA.

Jie Yuan (J)

Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, AL 35294, USA.

Eistine Boateng (E)

Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, AL 35294, USA.

Seantel Hopkins (S)

Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, AL 35294, USA.

Jin-San Zhang (JS)

School of Pharmaceutical Sciences and the First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Division of Oncology Research and Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, MN 55905, USA.

Victor J Thannickal (VJ)

Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, AL 35294, USA.

Reinhard Fässler (R)

Department of Molecular Medicine, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany.

Stijn P De Langhe (SP)

Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, AL 35294, USA sdelanghe@uabmc.edu.
ORCID: 0000-0003-3867-4572

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines adaptatrices de la transduction du signal › Hippo signaling promotes lung epithelial...
questionsmedicales.fr › Eucaryotes › Animaux › Hippo signaling promotes lung epithelial...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cycle cellulaire › Hippo signaling promotes lung epithelial...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Hippo signaling promotes lung epithelial...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Développement embryonnaire et foetal › Développement embryonnaire › Lignage cellulaire › Hippo signaling promotes lung epithelial...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Hippo signaling promotes lung epithelial...
questionsmedicales.fr › Cellules › Cellules épithéliales › Hippo signaling promotes lung epithelial...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Facteurs de croissance fibroblastique › Facteur de croissance fibroblastique de type 10 › Hippo signaling promotes lung epithelial...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Voie de signalisation Hippo › Hippo signaling promotes lung epithelial...
questionsmedicales.fr › Appareil respiratoire › Poumon › Hippo signaling promotes lung epithelial...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Hippo signaling promotes lung epithelial...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Hippo signaling promotes lung epithelial...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Développement embryonnaire et foetal › Organogenèse › Hippo signaling promotes lung epithelial...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Hippo signaling promotes lung epithelial...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Phosphoprotéines › Hippo signaling promotes lung epithelial...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Hippo signaling promotes lung epithelial...
questionsmedicales.fr › Appareil respiratoire › Poumon › Alvéoles pulmonaires › Hippo signaling promotes lung epithelial...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Hippo signaling promotes lung epithelial...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales régulatrices ou accessoires › Transactivateurs › Hippo signaling promotes lung epithelial...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines adaptatrices de la transduction du signal › Protéines de signalisation YAP › Hippo signaling promotes lung epithelial...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › bêta-Caténine › Hippo signaling promotes lung epithelial...