The Nonstructural NS1 Protein of Influenza Viruses Modulates
A549 Cells
Alternative Splicing
/ immunology
Cell Line, Tumor
Humans
Immunity, Innate
/ immunology
Influenza A virus
/ immunology
Influenza, Human
/ immunology
Interferons
/ immunology
Tumor Suppressor Protein p53
/ immunology
Viral Nonstructural Proteins
/ immunology
Virus Replication
/ immunology
mRNA Cleavage and Polyadenylation Factors
/ immunology
CPSF30
antiviral response
influenza viruses
p53
splicing
virus-host interactions
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
01 04 2019
01 04 2019
Historique:
received:
06
12
2018
accepted:
04
01
2019
pubmed:
18
1
2019
medline:
19
11
2019
entrez:
18
1
2019
Statut:
epublish
Résumé
Influenza A viruses (IAV) are known to modulate and "hijack" several cellular host mechanisms, including gene splicing and RNA maturation machineries. These modulations alter host cellular responses and enable an optimal expression of viral products throughout infection. The interplay between the host protein p53 and IAV, in particular through the viral nonstructural protein NS1, has been shown to be supportive for IAV replication. However, it remains unknown whether alternatively spliced isoforms of p53, known to modulate p53 transcriptional activity, are affected by IAV infection and contribute to IAV replication. Using a
Identifiants
pubmed: 30651364
pii: JVI.02168-18
doi: 10.1128/JVI.02168-18
pmc: PMC6430556
pii:
doi:
Substances chimiques
INS1 protein, influenza virus
0
TP53 protein, human
0
Tumor Suppressor Protein p53
0
Viral Nonstructural Proteins
0
mRNA Cleavage and Polyadenylation Factors
0
Interferons
9008-11-1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2019 American Society for Microbiology.
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