Radiation-Induced Malignant Transformation of Preneoplastic and Normal Breast Primary Epithelial Cells.
Journal
Molecular cancer research : MCR
ISSN: 1557-3125
Titre abrégé: Mol Cancer Res
Pays: United States
ID NLM: 101150042
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
04
09
2018
revised:
20
11
2018
accepted:
07
01
2019
pubmed:
18
1
2019
medline:
10
1
2020
entrez:
18
1
2019
Statut:
ppublish
Résumé
Radiation is used in multiple procedures as a therapeutic and diagnostic tool. However, ionizing radiation can induce mutations in the DNA of irradiated cells, which can promote tumorigenesis. As malignant transformation is a process that takes many years, there are intermediate stages of cells that have initiated the process but have not yet evolved into cancer. The study here aimed to investigate the effect of ionizing radiation on normal and partially transformed human mammary epithelial cells. Breast primary epithelial cells were derived from normal breast tissue from two different donors and modified by transduction with the SV40 small and large T antigen and
Identifiants
pubmed: 30651374
pii: 1541-7786.MCR-18-0938
doi: 10.1158/1541-7786.MCR-18-0938
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
937-948Informations de copyright
©2019 American Association for Cancer Research.