The role of trait anxiety in associative learning during and after an aversive event.
Journal
Learning & memory (Cold Spring Harbor, N.Y.)
ISSN: 1549-5485
Titre abrégé: Learn Mem
Pays: United States
ID NLM: 9435678
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
05
10
2018
accepted:
17
12
2018
entrez:
18
1
2019
pubmed:
18
1
2019
medline:
15
1
2020
Statut:
epublish
Résumé
Trait anxiety is considered to be a risk factor for anxiety disorders. The aim of the present study was to investigate how trait anxiety affects associative learning during and after an aversive event in laboratory rats. For this, rats were first submitted to a light-dark box test, followed by relief, safety, and fear learning. Our data demonstrate that all types of learning were affected by trait anxiety, both on a group and on an individual level. Whereas high levels of anxiety impaired relief and safety learning, fear learning was more pronounced. These findings help to show how trait anxiety might be involved in the etiology of anxiety disorders and pathological sensation- and risk-seeking.
Identifiants
pubmed: 30651378
pii: 26/2/56
doi: 10.1101/lm.048595.118
pmc: PMC6340115
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
56-59Informations de copyright
© 2019 Ilse et al.; Published by Cold Spring Harbor Laboratory Press.
Références
Behav Brain Res. 2017 Mar 1;320:210-218
pubmed: 27965038
Horm Behav. 2003 Nov;44(4):338-45
pubmed: 14613728
Eur J Pharmacol. 2003 Feb 28;463(1-3):55-65
pubmed: 12600702
Nat Rev Neurosci. 2004 Nov;5(11):844-52
pubmed: 15496862
Neuroscience. 2006 Jul 7;140(3):769-78
pubmed: 16581194
Neurobiol Learn Mem. 2017 Nov;145:105-113
pubmed: 28893668
Am J Psychiatry. 2010 Jan;167(1):47-55
pubmed: 19917595
J Anxiety Disord. 2004;18(5):587-607
pubmed: 15275941
Neuron. 2008 Oct 9;60(1):149-61
pubmed: 18940595
Learn Mem. 2012 Oct 16;19(11):518-26
pubmed: 23073641
Neurosci Biobehav Rev. 1999 May;23(5):743-60
pubmed: 10392663
Front Psychiatry. 2017 May 22;8:88
pubmed: 28588508
Behav Brain Res. 2014 Oct 1;272:40-5
pubmed: 24995614
Clin Psychol Rev. 2007 Jan;27(1):114-26
pubmed: 16997437
Behav Res Ther. 2005 Nov;43(11):1391-424
pubmed: 15885654
Br J Pharmacol. 2011 Oct;164(4):1129-61
pubmed: 21545412
Learn Mem. 2014 Mar 18;21(4):232-52
pubmed: 24643725
Neuron. 2012 Feb 23;73(4):653-76
pubmed: 22365542
Neuroimage. 2011 Apr 15;55(4):1878-88
pubmed: 21256233
Neuropharmacology. 2012 Feb;62(2):695-704
pubmed: 21377482
PLoS One. 2011 Apr 07;6(4):e17870
pubmed: 21490964
Biol Psychol. 2013 Feb;92(2):342-52
pubmed: 23174693
Behav Res Ther. 2009 Feb;47(2):111-8
pubmed: 19027893
PLoS One. 2011 Feb 28;6(2):e16849
pubmed: 21386891