3D printed poly(ε-caprolactone) scaffolds function with simvastatin-loaded poly(lactic-co-glycolic acid) microspheres to repair load-bearing segmental bone defects.
3D printing
artificial bone
bone defect
control release
microspheres
simvastatin
Journal
Experimental and therapeutic medicine
ISSN: 1792-0981
Titre abrégé: Exp Ther Med
Pays: Greece
ID NLM: 101531947
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
01
02
2018
accepted:
09
08
2018
entrez:
18
1
2019
pubmed:
18
1
2019
medline:
18
1
2019
Statut:
ppublish
Résumé
Repairing critical-sized bone defects has been a major challenge for orthopedic surgeons in the clinic. The generation of functioning bone tissue scaffolds using osteogenic induction factors is a promising method to facilitate bone healing. In the present study, three-dimensional (3D) printing of a poly(lactic-co-glycolic acid) (PLGA) scaffold with simvastatin (SIM) release functioning was generated by rapid prototyping, which was incorporated with collagen for surface activation, and was finally mixed with SIM-loaded PLGA microspheres.
Identifiants
pubmed: 30651767
doi: 10.3892/etm.2018.6947
pii: ETM-0-0-6947
pmc: PMC6307523
doi:
Types de publication
Journal Article
Langues
eng
Pagination
79-90Références
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