FUSE binding protein 1 (FUBP1) expression is upregulated by T-cell acute lymphocytic leukemia protein 1 (TAL1) and required for efficient erythroid differentiation.
A549 Cells
Cell Differentiation
/ genetics
DNA-Binding Proteins
/ genetics
Erythroid Precursor Cells
/ metabolism
Erythropoiesis
/ genetics
GATA1 Transcription Factor
/ genetics
Gene Expression Regulation, Neoplastic
HEK293 Cells
HL-60 Cells
Humans
RNA-Binding Proteins
/ genetics
T-Cell Acute Lymphocytic Leukemia Protein 1
/ genetics
Up-Regulation
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2019
2019
Historique:
received:
21
08
2018
accepted:
23
12
2018
entrez:
18
1
2019
pubmed:
18
1
2019
medline:
19
11
2019
Statut:
epublish
Résumé
During erythropoiesis, haematopoietic stem cells (HSCs) differentiate in successive steps of commitment and specification to mature erythrocytes. This differentiation process is controlled by transcription factors that establish stage- and cell type-specific gene expression. In this study, we demonstrate that FUSE binding protein 1 (FUBP1), a transcriptional regulator important for HSC self-renewal and survival, is regulated by T-cell acute lymphocytic leukaemia 1 (TAL1) in erythroid progenitor cells. TAL1 directly activates the FUBP1 promoter, leading to increased FUBP1 expression during erythroid differentiation. The binding of TAL1 to the FUBP1 promoter is highly dependent on an intact GATA sequence in a combined E-box/GATA motif. We found that FUBP1 expression is required for efficient erythropoiesis, as FUBP1-deficient progenitor cells were limited in their potential of erythroid differentiation. Thus, the finding of an interconnection between GATA1/TAL1 and FUBP1 reveals a molecular mechanism that is part of the switch from progenitor- to erythrocyte-specific gene expression. In summary, we identified a TAL1/FUBP1 transcriptional relationship, whose physiological function in haematopoiesis is connected to proper erythropoiesis.
Identifiants
pubmed: 30653565
doi: 10.1371/journal.pone.0210515
pii: PONE-D-18-24611
pmc: PMC6336336
doi:
Substances chimiques
DNA-Binding Proteins
0
FUBP1 protein, human
0
GATA1 Transcription Factor
0
GATA1 protein, human
0
RNA-Binding Proteins
0
T-Cell Acute Lymphocytic Leukemia Protein 1
0
TAL1 protein, human
135471-20-4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0210515Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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