Non-invasive monitoring of subclinical and clinical actinic keratosis of face and scalp under topical treatment with ingenol mebutate gel 150 mcg/g by means of reflectance confocal microscopy and optical coherence tomography: New perspectives and comparison of diagnostic techniques.
actinic keratosis
cancerization field
dermoscopy
ingenol mebutate
non-melanoma skin cancer
reflectance confocal microscopy
squamous cell carcinoma
subclinical lesions
topical therapy of skin cancer
Journal
Journal of biophotonics
ISSN: 1864-0648
Titre abrégé: J Biophotonics
Pays: Germany
ID NLM: 101318567
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
14
10
2018
revised:
12
01
2019
accepted:
13
01
2019
pubmed:
18
1
2019
medline:
9
9
2020
entrez:
18
1
2019
Statut:
ppublish
Résumé
Actinic keratosis (AK) corresponds to the earliest stage of in situ squamous cell carcinoma and arises on chronically sun-exposed skin. Around the clinically evident AKs, the apparently healthy epidermis may contain different grades of atypia that can be detected by noninvasive imaging techniques such as reflectance confocal microscopy (RCM) and optical coherence tomography (OCT). Subclinical actinic keratosis (sAK) has captured increasing interest as a potential target of field therapies. The aim of this study was to evaluate in vivo the changes in the field cancerization undergoing treatment with topical ingenol mebutate by combining RCM and OCT. Twenty patients with field cancerization of the face and scalp were treated with ingenol mebutate gel (150 mcg/g) for three consecutive days on an area of 25 cm
Identifiants
pubmed: 30653833
doi: 10.1002/jbio.201800391
doi:
Substances chimiques
3-ingenyl angelate
0
Diterpenes
0
Types de publication
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e201800391Subventions
Organisme : Leo Pharma
Pays : International
Informations de copyright
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.