IL-21 promotes allergic airway inflammation by driving apoptosis of FoxP3
IL-21
asthma
colitis
mucosal immunity
regulatory T cells
Journal
The Journal of allergy and clinical immunology
ISSN: 1097-6825
Titre abrégé: J Allergy Clin Immunol
Pays: United States
ID NLM: 1275002
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
04
04
2018
revised:
05
10
2018
accepted:
30
11
2018
pubmed:
18
1
2019
medline:
9
6
2020
entrez:
18
1
2019
Statut:
ppublish
Résumé
IL-21 is a key player of adaptive immunity, with well-established roles in B-cell and cytotoxic T-cell responses. IL-21 has been implicated in promotion of effector CD4 We sought to understand the mechanisms by which IL-21 controls effector CD4 We used IL-21 receptor-deficient mice to study the effect of IL-21 on T-cell responses in models of asthma and colitis. We used mixed bone marrow chimeras and adoptive transfer of naive CD4 We show that IL-21 production by T IL-21 directly promotes apoptosis of Treg cells and therefore indirectly sustains generation of inflammatory T
Sections du résumé
BACKGROUND
IL-21 is a key player of adaptive immunity, with well-established roles in B-cell and cytotoxic T-cell responses. IL-21 has been implicated in promotion of effector CD4
OBJECTIVE
We sought to understand the mechanisms by which IL-21 controls effector CD4
METHODS
We used IL-21 receptor-deficient mice to study the effect of IL-21 on T-cell responses in models of asthma and colitis. We used mixed bone marrow chimeras and adoptive transfer of naive CD4
RESULTS
We show that IL-21 production by T
CONCLUSION
IL-21 directly promotes apoptosis of Treg cells and therefore indirectly sustains generation of inflammatory T
Identifiants
pubmed: 30654048
pii: S0091-6749(19)30009-0
doi: 10.1016/j.jaci.2018.11.047
pii:
doi:
Substances chimiques
Forkhead Transcription Factors
0
Foxp3 protein, mouse
0
Il21r protein, mouse
0
Interleukin-21 Receptor alpha Subunit
0
Interleukins
0
interleukin-21
MKM3CA6LT1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2178-2189.e5Informations de copyright
Copyright © 2019 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.