Serum IgG Concentrations in Adult Patients Experiencing Virus-Induced Severe Asthma Exacerbations.
Administration, Oral
Adrenal Cortex Hormones
/ therapeutic use
Adult
Asthma
/ drug therapy
Coronavirus Infections
/ immunology
Disease Progression
Enterovirus Infections
/ immunology
Female
Hospitalization
Humans
Immunoglobulin G
/ immunology
Influenza, Human
/ immunology
Length of Stay
Male
Middle Aged
Multiplex Polymerase Chain Reaction
Nasopharynx
/ virology
Paramyxoviridae Infections
/ immunology
Picornaviridae Infections
/ immunology
Respiratory Syncytial Virus Infections
/ immunology
Respiratory Tract Infections
/ immunology
Severity of Illness Index
Virus Diseases
/ immunology
Asthma
Exacerbation
IgG
Virus
Journal
The journal of allergy and clinical immunology. In practice
ISSN: 2213-2201
Titre abrégé: J Allergy Clin Immunol Pract
Pays: United States
ID NLM: 101597220
Informations de publication
Date de publication:
Historique:
received:
30
05
2018
revised:
26
12
2018
accepted:
28
12
2018
pubmed:
18
1
2019
medline:
18
8
2020
entrez:
18
1
2019
Statut:
ppublish
Résumé
Patients experiencing severe asthma exacerbations have a poorer quality of life and an increase in morbidity and mortality. Viruses are frequently involved in asthma exacerbations. To determine the value of measuring serum IgG concentrations in asthma exacerbations and assess their link with viral infections in patients hospitalized for asthma. Patients hospitalized for asthma exacerbation were included in an observational study from January 1, 2015, to December 31, 2015. Serum IgG concentrations on admission were compared between patients with a positive upper airway viral sample and those with a negative viral sample. Among the 82 patients included, those with positive viral nasopharyngeal samples (n = 40) presented with lower serum IgG concentrations during exacerbation than those with a negative viral sample (n = 42) (10.1 ± 2.3 g/L vs 11.5 ± 3.6 g/L; P < .05). The median concentration of serum IgG was lower in patients hospitalized for more than 3 days compared with those hospitalized for less than 3 days (10.0 g/L [8.2-12.4] vs 11.4 g/L [10.1-12.8]; P < .05) and in patients who received oral corticosteroid therapy for more than 5 days compared with those treated with oral steroids for less than 5 days (10.1 g/L [8.3-12.2] vs 11.6 g/L [10.0-13.8]; P < .05). Serum IgG level was significantly lower when asthma exacerbations were associated with positive viral samples. The patients with lower serum IgG concentrations required longer hospitalizations and longer courses of steroids.
Sections du résumé
BACKGROUND
Patients experiencing severe asthma exacerbations have a poorer quality of life and an increase in morbidity and mortality. Viruses are frequently involved in asthma exacerbations.
OBJECTIVE
To determine the value of measuring serum IgG concentrations in asthma exacerbations and assess their link with viral infections in patients hospitalized for asthma.
METHODS
Patients hospitalized for asthma exacerbation were included in an observational study from January 1, 2015, to December 31, 2015. Serum IgG concentrations on admission were compared between patients with a positive upper airway viral sample and those with a negative viral sample.
RESULTS
Among the 82 patients included, those with positive viral nasopharyngeal samples (n = 40) presented with lower serum IgG concentrations during exacerbation than those with a negative viral sample (n = 42) (10.1 ± 2.3 g/L vs 11.5 ± 3.6 g/L; P < .05). The median concentration of serum IgG was lower in patients hospitalized for more than 3 days compared with those hospitalized for less than 3 days (10.0 g/L [8.2-12.4] vs 11.4 g/L [10.1-12.8]; P < .05) and in patients who received oral corticosteroid therapy for more than 5 days compared with those treated with oral steroids for less than 5 days (10.1 g/L [8.3-12.2] vs 11.6 g/L [10.0-13.8]; P < .05).
CONCLUSIONS
Serum IgG level was significantly lower when asthma exacerbations were associated with positive viral samples. The patients with lower serum IgG concentrations required longer hospitalizations and longer courses of steroids.
Identifiants
pubmed: 30654200
pii: S2213-2198(19)30054-6
doi: 10.1016/j.jaip.2018.12.028
pmc: PMC7104119
pii:
doi:
Substances chimiques
Adrenal Cortex Hormones
0
Immunoglobulin G
0
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
1507-1513.e1Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2019 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.
Références
BMJ. 1995 May 13;310(6989):1225-9
pubmed: 7767192
J Allergy Clin Immunol. 2007 Feb;119(2):314-21
pubmed: 17140648
Allergy. 2010 Apr;65(4):510-5
pubmed: 19839975
Lancet. 2002 Mar 9;359(9309):831-4
pubmed: 11897281
J Allergy Clin Immunol. 2017 Oct;140(4):1164-1167.e6
pubmed: 28456620
Am J Respir Crit Care Med. 2011 Nov 1;184(9):1007-14
pubmed: 21816938
Hum Vaccin Immunother. 2012 Apr;8(4):443-7
pubmed: 22370516
Am J Respir Crit Care Med. 1996 Sep;154(3 Pt 1):654-60
pubmed: 8810601
J Allergy Clin Immunol. 2005 Jan;115(1):132-8
pubmed: 15637559
Eur Respir J. 2015 Sep;46(3):622-39
pubmed: 26206872
Respirology. 2014 Jan;19(1):116-21
pubmed: 23931674
Chest. 2004 Mar;125(3):1081-102
pubmed: 15006973
J Allergy Clin Immunol. 2009 Aug;124(2 Suppl):S5-14
pubmed: 19647135
J Allergy Clin Immunol. 2012 Aug;130(2):489-95
pubmed: 22766097
J Allergy Clin Immunol. 2010 Jul;126(1):120-6
pubmed: 20541246
Chest. 2007 Feb;131(2):415-23
pubmed: 17296642
Laryngoscope. 1996 Oct;106(10):1298-305
pubmed: 8849805
Thorax. 2006 Aug;61(8):722-8
pubmed: 16877691
Respiration. 2002;69(2):136-42
pubmed: 11961427
Pediatr Infect Dis J. 2014 Oct;33(10):1016-22
pubmed: 24830696
Immunol Rev. 2008 Dec;226:172-90
pubmed: 19161424
J Allergy Clin Immunol. 2005 Aug;116(2):267-73
pubmed: 16083778
J Allergy Clin Immunol. 2000 Feb;105(2 Pt 1):193-204
pubmed: 10669837
Acad Pediatr. 2015 Mar-Apr;15(2):225-30
pubmed: 25596899
Thorax. 2006 Sep;61(9):744-6
pubmed: 16936234
J Immunol. 2004 Aug 1;173(3):1978-86
pubmed: 15265932
Am J Respir Crit Care Med. 2012 Jun 15;185(12):1275-9
pubmed: 22366048
J Allergy Clin Immunol. 2012 Mar;129(3 Suppl):S34-48
pubmed: 22386508
Clin Exp Allergy. 2009 Feb;39(2):193-202
pubmed: 19187331
J Infect Dis. 2003 Apr 15;187(8):1314-8
pubmed: 12696012
Eur Respir J. 2017 Mar 8;49(3):
pubmed: 28275176
Eur Respir J. 1993 Mar;6 Suppl 16:5-40
pubmed: 24576915
J Allergy Clin Immunol. 2017 Oct;140(4):895-906
pubmed: 28987219
Hong Kong Med J. 2013 Jun;19 Suppl 4:11-4
pubmed: 23775180
Am J Respir Crit Care Med. 2006 Sep 15;174(6):633-8
pubmed: 16778163
Proc Am Thorac Soc. 2007 Dec;4(8):591-6
pubmed: 18073388
PLoS Med. 2011 Jul;8(7):e1001053
pubmed: 21750667
J Allergy Clin Immunol. 2014 Jul;134(1):25-32
pubmed: 24767874