Pre- and postnatal environmental boron exposure and infant growth: Results from a mother-child cohort in northern Argentina.
Blood
Boron exposure
Breast milk
Drinking water
Infant anthropometry
Urine
Journal
Environmental research
ISSN: 1096-0953
Titre abrégé: Environ Res
Pays: Netherlands
ID NLM: 0147621
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
01
11
2018
revised:
27
12
2018
accepted:
05
01
2019
pubmed:
18
1
2019
medline:
18
12
2019
entrez:
18
1
2019
Statut:
ppublish
Résumé
Experimental studies show developmental toxicity of boron and we recently found impaired weight and length in newborns of mothers exposed to boron through drinking water during pregnancy. To evaluate potential impact of pre- and postnatal boron exposure on infant anthropometry. In our mother-child cohort (n = 177) in Argentinean Andes, where drinking water concentrations of boron, lithium and arsenic have been found to vary considerably, we collected maternal blood and urine during and after pregnancy, placenta, breast milk, as well as infant urine and blood during the first 6 months of life. In all samples, boron and other potentially toxic elements were measured by ICP-MS. Infant weight (g), length (cm) and head circumference (cm) were measured at birth, 0-3 (n = 120) and/or 3-6 months (n = 120; 79 overlap) of age. Boron concentrations in breast milk (range: 46-786 µg/L) correlated strongly with those in maternal serum (range: 47-624 µg/L; r The observed first evidence that elevated environmental boron exposure in early infancy may adversely affect growth supports previous findings of boron-related impaired fetal growth. More research is needed to verify the findings at older age and in other populations.
Sections du résumé
BACKGROUND
Experimental studies show developmental toxicity of boron and we recently found impaired weight and length in newborns of mothers exposed to boron through drinking water during pregnancy.
OBJECTIVES
To evaluate potential impact of pre- and postnatal boron exposure on infant anthropometry.
METHODS
In our mother-child cohort (n = 177) in Argentinean Andes, where drinking water concentrations of boron, lithium and arsenic have been found to vary considerably, we collected maternal blood and urine during and after pregnancy, placenta, breast milk, as well as infant urine and blood during the first 6 months of life. In all samples, boron and other potentially toxic elements were measured by ICP-MS. Infant weight (g), length (cm) and head circumference (cm) were measured at birth, 0-3 (n = 120) and/or 3-6 months (n = 120; 79 overlap) of age.
RESULTS
Boron concentrations in breast milk (range: 46-786 µg/L) correlated strongly with those in maternal serum (range: 47-624 µg/L; r
CONCLUSIONS
The observed first evidence that elevated environmental boron exposure in early infancy may adversely affect growth supports previous findings of boron-related impaired fetal growth. More research is needed to verify the findings at older age and in other populations.
Identifiants
pubmed: 30654250
pii: S0013-9351(19)30012-X
doi: 10.1016/j.envres.2019.01.012
pii:
doi:
Substances chimiques
Environmental Pollutants
0
Boron
N9E3X5056Q
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
60-68Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.