Executive Function in Fragile X Syndrome: A Systematic Review.
attention
cognitive flexibility
executive function
fragile X syndrome
inhibitory control
planning
processing speed
set-shifting
working memory
Journal
Brain sciences
ISSN: 2076-3425
Titre abrégé: Brain Sci
Pays: Switzerland
ID NLM: 101598646
Informations de publication
Date de publication:
16 Jan 2019
16 Jan 2019
Historique:
received:
15
12
2018
revised:
09
01
2019
accepted:
11
01
2019
entrez:
19
1
2019
pubmed:
19
1
2019
medline:
19
1
2019
Statut:
epublish
Résumé
Executive function (EF) supports goal-directed behavior and includes key aspects such as working memory, inhibitory control, cognitive flexibility, attention, processing speed, and planning. Fragile X syndrome (FXS) is the leading inherited monogenic cause of intellectual disability and is phenotypically characterized by EF deficits beyond what is expected given general cognitive impairments. Yet, a systematic review of behavioral studies using performance-based measures is needed to provide a summary of EF deficits across domains in males and females with FXS, discuss clinical and biological correlates of these EF deficits, identify critical limitations in available research, and offer suggestions for future studies in this area. Ultimately, this review aims to advance our understanding of the underlying pathophysiological mechanisms contributing to EF in FXS and to inform the development of outcome measures of EF and identification of new treatment targets in FXS.
Identifiants
pubmed: 30654486
pii: brainsci9010015
doi: 10.3390/brainsci9010015
pmc: PMC6356760
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : NICHD NIH HHS
ID : R01 HD076189
Pays : United States
Organisme : National Institute of Mental Health/National Institute of Child Health and Human Development
ID : U54 HD082008-01
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