Aquaporins in Renal Diseases.
acute kidney injury
aquaporin
diabetic nephropathy
nephrogenic diabetes insipidus
polycystic kidney disease
renal cell carcinoma
vasopressin
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
16 Jan 2019
16 Jan 2019
Historique:
received:
25
12
2018
revised:
11
01
2019
accepted:
14
01
2019
entrez:
19
1
2019
pubmed:
19
1
2019
medline:
30
4
2019
Statut:
epublish
Résumé
Aquaporins (AQPs) are a family of highly selective transmembrane channels that mainly transport water across the cell and some facilitate low-molecular-weight solutes. Eight AQPs, including AQP1, AQP2, AQP3, AQP4, AQP5, AQP6, AQP7, and AQP11, are expressed in different segments and various cells in the kidney to maintain normal urine concentration function. AQP2 is critical in regulating urine concentrating ability. The expression and function of AQP2 are regulated by a series of transcriptional factors and post-transcriptional phosphorylation, ubiquitination, and glycosylation. Mutation or functional deficiency of AQP2 leads to severe nephrogenic diabetes insipidus. Studies with animal models show AQPs are related to acute kidney injury and various chronic kidney diseases, such as diabetic nephropathy, polycystic kidney disease, and renal cell carcinoma. Experimental data suggest ideal prospects for AQPs as biomarkers and therapeutic targets in clinic. This review article mainly focuses on recent advances in studying AQPs in renal diseases.
Identifiants
pubmed: 30654539
pii: ijms20020366
doi: 10.3390/ijms20020366
pmc: PMC6359174
pii:
doi:
Substances chimiques
Aquaporins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Natural Science Foundation of China
ID : 81620108029, 81261160507, 81330074, 81170632, and 81370783
Organisme : Beijing Natural Science Foundation
ID : 7172113, and the 111 Project
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