Chiral Derivatives of Xanthones with Antimicrobial Activity.

Anti-Infective Agents / chemical synthesis Biological Products / chemistry Drug Resistance, Bacterial / drug effects Drug Resistance, Fungal / drug effects Humans Molecular Structure Plant Extracts / chemistry Structure-Activity Relationship Xanthones / chemical synthesis
antimicrobial caged xanthones chiral derivatives of xanthones chirality xanthones

Journal

Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009

Informations de publication

Date de publication:
16 Jan 2019
Historique:
received: 30 12 2018
revised: 12 01 2019
accepted: 14 01 2019
entrez: 19 1 2019
pubmed: 19 1 2019
medline: 4 4 2019
Statut: epublish

Résumé

According to the World Health Organization, the exacerbated use of antibiotics worldwide is increasing multi-resistant infections, especially in the last decade. Xanthones are a class of compounds receiving great interest in drug discovery and development that can be found as natural products or obtained by synthesis. Many derivatives of xanthones are chiral and associated with relevant biological activities, including antimicrobial. The aim of this review is to compile information about chiral derivatives of xanthones from natural sources and their synthesized examples with antimicrobial activity.

Identifiants

DOI: 10.3390/molecules24020314 PMID: 30654546 PMC: PMC6359477
pubmed: 30654546
pii: molecules24020314
doi: 10.3390/molecules24020314
pmc: PMC6359477
pii:
doi:

Substances chimiques

Anti-Infective Agents 0
Biological Products 0
Plant Extracts 0
Xanthones 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : No. POCI-01-0145-FEDER-028736
ID : PTDC/ MAR-BIO/4694/2014
Organisme : Cooperativa de Ensino Superior Politécnico e Universitário
ID : CHIRALXANT-CESPU-2018

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Auteurs

Joana Araújo (J)

Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. up201703236@ff.up.pt.

Carla Fernandes (C)

Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. cfernandes@ff.up.pt.
Interdisciplinary Center of Marine and Environmental Research (CIIMAR), University of Porto, Edificio do Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4050-208 Matosinhos, Portugal. cfernandes@ff.up.pt.
ORCID: 0000-0003-0940-9163

Madalena Pinto (M)

Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. madalena@ff.up.pt.
Interdisciplinary Center of Marine and Environmental Research (CIIMAR), University of Porto, Edificio do Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4050-208 Matosinhos, Portugal. madalena@ff.up.pt.
ORCID: 0000-0002-4676-1409

Maria Elizabeth Tiritan (ME)

Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. elizabeth.tiritan@iucs.cespu.pt.
Interdisciplinary Center of Marine and Environmental Research (CIIMAR), University of Porto, Edificio do Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4050-208 Matosinhos, Portugal. elizabeth.tiritan@iucs.cespu.pt.
Institute of Research and Advanced Training in Health Sciences and Technologies, Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Rua Central de Gandra, 1317, 4585-116 Gandra PRD, Portugal. elizabeth.tiritan@iucs.cespu.pt.
ORCID: 0000-0003-3320-730X

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Chiral Derivatives of Xanthones with...
questionsmedicales.fr › Mélanges complexes › Produits biologiques › Chiral Derivatives of Xanthones with...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance microbienne aux médicaments › Résistance bactérienne aux médicaments › Chiral Derivatives of Xanthones with...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance microbienne aux médicaments › Résistance des champignons aux médicaments › Chiral Derivatives of Xanthones with...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Chiral Derivatives of Xanthones with...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Chiral Derivatives of Xanthones with...
questionsmedicales.fr › Préparations pharmaceutiques › Extraits de plantes › Chiral Derivatives of Xanthones with...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Chiral Derivatives of Xanthones with...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérocycliques 3 noyaux › Xanthènes › Xanthones › Chiral Derivatives of Xanthones with...