Renal Adiposity Does not Preclude Quantitative Assessment of Renal Function Using Dual-Energy Multidetector CT in Mildly Obese Human Subjects.
Dual Energy Computed Tomography
Intrarenal fat
Iodine maps
Obesity
Renal perfusion
Journal
Academic radiology
ISSN: 1878-4046
Titre abrégé: Acad Radiol
Pays: United States
ID NLM: 9440159
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
18
09
2018
revised:
10
12
2018
accepted:
10
12
2018
pubmed:
19
1
2019
medline:
17
6
2020
entrez:
19
1
2019
Statut:
ppublish
Résumé
Multidetector computed tomography (MDCT) is useful for measuring in the research setting single-kidney perfusion and function using iodinated contrast time-attenuation curves. Obesity promotes deposition of intrarenal fat, which might decrease tissue attenuation and thereby interfere with quantification of renal function using MDCT. The purpose of this study was to test the hypothesis that background subtraction adequately accounts for intrarenal fat deposition in mildly obese human subjects during renal contrast enhanced dynamic CT. We prospectively recruited seventeen human subjects stratified as lean or mildly obese based on body mass index below or over 30 kg/m Subcutaneous adipose tissue was increased in obese subjects. Virtual-noncontrast maps revealed in obese patients a decrease in basal cortical and medullary attenuation. Overall, basal attenuation inversely correlated with body mass index, in line with renal fat deposition. Contrarily, the kidney/aorta CT attenuation (after background subtraction) and kidney/aorta iodine ratios were similar between lean and obese subjects and correlated directly. These observations show that following background subtraction, the CT number reliably reflects basal tissue attenuation. Therefore, our findings support our hypothesis that background subtraction enables reliable assessment of kidney function in mildly obese subjects using MDCT, despite decreased basal attenuation due to renal adiposity.
Identifiants
pubmed: 30655055
pii: S1076-6332(19)30001-7
doi: 10.1016/j.acra.2018.12.008
pmc: PMC6626692
mid: NIHMS1518699
pii:
doi:
Substances chimiques
Contrast Media
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1488-1494Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK100081
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK104273
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK102325
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK120292
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL123160
Pays : United States
Organisme : NCRR NIH HHS
ID : C06 RR018898
Pays : United States
Informations de copyright
Copyright © 2019 The Association of University Radiologists. Published by Elsevier Inc. All rights reserved.
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