Hepatobiliary Scintigraphy in the Preoperative Evaluation of Potential Living Liver Donors.
Journal
Transplantation proceedings
ISSN: 1873-2623
Titre abrégé: Transplant Proc
Pays: United States
ID NLM: 0243532
Informations de publication
Date de publication:
Historique:
received:
10
02
2018
accepted:
13
04
2018
pubmed:
19
1
2019
medline:
29
3
2019
entrez:
19
1
2019
Statut:
ppublish
Résumé
Graft selection strategy in living donor liver transplantation (LDLT) is usually multifactorial, but special attention is paid to the determination of donor liver volumes to minimize any risk of posthepatectomy liver failure (PHLF). Hepatobiliary scintigraphy (HBS) with single-photon-emission computed tomography allows for the measurement of total and future liver remnant function (FLR-F) and has been shown to predict the risk of PHLF more accurately than liver volumetry. Since November 2016, HBS has been performed at our Institution in every candidate to major hepatectomy, including potential living liver donors. Thirty-seven consecutive patients were submitted to HBS, of whom 7 were potential living liver donors. After completed hepatectomy (n = 27), the median FLR-F of patients who developed PHLF (n = 9) was 1.72%/min/m The present study suggests that a non-invasive low-cost exam such as HBS may be a promising tool to predict PHLF not only in neoplastic patients but also to evaluate potential living donors. Larger studies are needed to draw any conclusion regarding the benefits of HBS in the living liver donor workup.
Sections du résumé
BACKGROUND
BACKGROUND
Graft selection strategy in living donor liver transplantation (LDLT) is usually multifactorial, but special attention is paid to the determination of donor liver volumes to minimize any risk of posthepatectomy liver failure (PHLF). Hepatobiliary scintigraphy (HBS) with single-photon-emission computed tomography allows for the measurement of total and future liver remnant function (FLR-F) and has been shown to predict the risk of PHLF more accurately than liver volumetry.
METHODS
METHODS
Since November 2016, HBS has been performed at our Institution in every candidate to major hepatectomy, including potential living liver donors.
RESULTS
RESULTS
Thirty-seven consecutive patients were submitted to HBS, of whom 7 were potential living liver donors. After completed hepatectomy (n = 27), the median FLR-F of patients who developed PHLF (n = 9) was 1.72%/min/m
CONCLUSIONS
CONCLUSIONS
The present study suggests that a non-invasive low-cost exam such as HBS may be a promising tool to predict PHLF not only in neoplastic patients but also to evaluate potential living donors. Larger studies are needed to draw any conclusion regarding the benefits of HBS in the living liver donor workup.
Identifiants
pubmed: 30655158
pii: S0041-1345(18)30875-3
doi: 10.1016/j.transproceed.2018.04.087
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
167-170Informations de copyright
Copyright © 2018 Elsevier Inc. All rights reserved.