Blood Pressure, Sexual Activity, and Erectile Function in Hypertensive Men: Baseline Findings from the Systolic Blood Pressure Intervention Trial (SPRINT).
Erectile Function
Hypertension
Older Men
Sexual Activity
Sexual Function
Journal
The journal of sexual medicine
ISSN: 1743-6109
Titre abrégé: J Sex Med
Pays: Netherlands
ID NLM: 101230693
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
12
09
2018
revised:
29
11
2018
accepted:
06
12
2018
pubmed:
19
1
2019
medline:
27
3
2020
entrez:
19
1
2019
Statut:
ppublish
Résumé
Erectile function, an important aspect of quality of life, is gaining increased research and clinical attention in older men with hypertension. To assess the cross-sectional association between blood pressure measures (systolic blood pressure [SBP]; diastolic blood pressure [DBP]; and pulse pressure [PP]) and (i) sexual activity and (ii) erectile function in hypertensive men. We performed analyses of 1,255 male participants in a larger randomized clinical trial of 9,361 men and women with hypertension aged ≥50 years. The main outcome measures were self-reported sexual activity (yes/no) and erectile function using the 5-item International Index of Erectile Function (IIEF-5). 857 participants (68.3%) reported being sexually active during the previous 4 weeks. The mean (SD) IIEF-5 score for sexually active participants was 18.0 (5.8), and 59.9% of the sample reported an IIEF-5 score <21, suggesting erectile dysfunction (ED). In adjusted logistic regression models, neither SBP (adjusted odds ratio = 0.998; P = .707) nor DBP (adjusted odds ratio = 1.001; P = .929) was significantly associated with sexual activity. In multivariable linear regression analyses in sexually active participants, lower SBP (β = -0.04; P = .025) and higher DBP (β = 0.05; P = .029) were associated with better erectile function. In additional multivariable analyses, lower PP pressure was associated with better erectile function (β = -0.04; P = .02). Blood pressure is an important consideration in the assessment of erectile function in men with hypertension. Assessments of blood pressure and clinical and psychosocial variables were performed using rigorous methods in this multi-ethnic and geographically diverse sample. However, these cross-sectional analyses did not include assessment of androgen or testosterone levels. Erectile dysfunction was highly prevalent in this sample of men with hypertension, and SBP, DBP, and PP were associated with erectile function in this sample. Foy CG, Newman JC, Berlowitz DR, et al. Blood Pressure, Sexual Activity, and Erectile Function in Hypertensive Men: Baseline Findings from the Systolic Blood Pressure Intervention Trial (SPRINT). J Sex Med 2019;16:235-247.
Identifiants
pubmed: 30655182
pii: S1743-6095(18)31381-X
doi: 10.1016/j.jsxm.2018.12.007
pmc: PMC6444897
mid: NIHMS1518741
pii:
doi:
Types de publication
Journal Article
Multicenter Study
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
235-247Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR000445
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000005
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268200900040C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268200900046C
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000064
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK061021
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000075
Pays : United States
Organisme : NCATS NIH HHS
ID : KL2 TR000440
Pays : United States
Organisme : NIGMS NIH HHS
ID : P30 GM103337
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001064
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR025752
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR025771
Pays : United States
Organisme : NCATS NIH HHS
ID : TL1 TR000441
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000093
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK045381
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268200900049C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268200900047C
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001427
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000003
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000073
Pays : United States
Organisme : NICHD NIH HHS
ID : K12 HD057581
Pays : United States
Organisme : NCRR NIH HHS
ID : KL2 RR024990
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000002
Pays : United States
Organisme : NIA NIH HHS
ID : K23 AG052628
Pays : United States
Organisme : NCRR NIH HHS
ID : M01 RR000080
Pays : United States
Informations de copyright
Copyright © 2019 International Society for Sexual Medicine. All rights reserved.
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