Ezrin Promotes Stem Cell Properties in Pancreatic Ductal Adenocarcinoma.
Actins
/ metabolism
Adamantane
/ analogs & derivatives
Animals
Carcinoma, Pancreatic Ductal
/ metabolism
Cell Line, Tumor
Cytoskeletal Proteins
/ antagonists & inhibitors
Heterografts
Humans
Mice
Mice, Nude
Neoplastic Stem Cells
/ metabolism
Pancreatic Neoplasms
/ metabolism
Quinolines
/ pharmacology
Journal
Molecular cancer research : MCR
ISSN: 1557-3125
Titre abrégé: Mol Cancer Res
Pays: United States
ID NLM: 101150042
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
14
04
2018
revised:
09
10
2018
accepted:
08
01
2019
pubmed:
19
1
2019
medline:
10
1
2020
entrez:
19
1
2019
Statut:
ppublish
Résumé
Self-renewal maintains the long-term clonogenic growth that is required for cancer relapse and progression, but the cellular processes regulating this property are not fully understood. In many diseases, self-renewal is enhanced in cancer stem cells (CSC), and in pancreatic ductal adenocarcinoma (PDAC), CSCs are characterized by the surface expression of CD44. In addition to cell adhesion, CD44 impacts cell shape and morphology by modulating the actin cytoskeleton via Ezrin, a member of the Ezrin/Radixin/Moesin (ERM) family of linker proteins. We examined the expression of Ezrin in PDAC cells and found higher levels of both total and activated Ezrin in CSCs compared with bulk tumor cells. We also found that the knockdown of Ezrin in PDAC cells decreased clonogenic growth, self-renewal, cell migration, and CSC frequency
Identifiants
pubmed: 30655325
pii: 1541-7786.MCR-18-0367
doi: 10.1158/1541-7786.MCR-18-0367
pmc: PMC6445733
mid: NIHMS1518806
doi:
Substances chimiques
Actins
0
Cytoskeletal Proteins
0
NSC305787
0
Quinolines
0
ezrin
0
Adamantane
PJY633525U
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
929-936Subventions
Organisme : NCI NIH HHS
ID : R01 CA150142
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA127574
Pays : United States
Organisme : NCI NIH HHS
ID : K24 CA198315
Pays : United States
Organisme : NCI NIH HHS
ID : K08 CA218893
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA193887
Pays : United States
Informations de copyright
©2019 American Association for Cancer Research.
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