Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins.
Journal
Nature reviews. Molecular cell biology
ISSN: 1471-0080
Titre abrégé: Nat Rev Mol Cell Biol
Pays: England
ID NLM: 100962782
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
pubmed:
19
1
2019
medline:
7
1
2020
entrez:
19
1
2019
Statut:
ppublish
Résumé
The loss of vital cells within healthy tissues contributes to the development, progression and treatment outcomes of many human disorders, including neurological and infectious diseases as well as environmental and medical toxicities. Conversely, the abnormal survival and accumulation of damaged or superfluous cells drive prominent human pathologies such as cancers and autoimmune diseases. Apoptosis is an evolutionarily conserved cell death pathway that is responsible for the programmed culling of cells during normal eukaryotic development and maintenance of organismal homeostasis. This pathway is controlled by the BCL-2 family of proteins, which contains both pro-apoptotic and pro-survival members that balance the decision between cellular life and death. Recent insights into the dynamic interactions between BCL-2 family proteins and how they control apoptotic cell death in healthy and diseased cells have uncovered novel opportunities for therapeutic intervention. Importantly, the development of both positive and negative small-molecule modulators of apoptosis is now enabling researchers to translate the discoveries that have been made in the laboratory into clinical practice to positively impact human health.
Identifiants
pubmed: 30655609
doi: 10.1038/s41580-018-0089-8
pii: 10.1038/s41580-018-0089-8
pmc: PMC7325303
mid: NIHMS1597632
doi:
Substances chimiques
Proto-Oncogene Proteins c-bcl-2
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
175-193Subventions
Organisme : NCI NIH HHS
ID : K99 CA188679
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA206978
Pays : United States
Organisme : NCI NIH HHS
ID : R00 CA188679
Pays : United States
Références
Dev Biol. 1997 Apr 1;184(1):115-21
pubmed: 9142988
Tumour Biol. 2010 Aug;31(4):363-72
pubmed: 20490962
Cancer Cell. 2017 Jan 9;31(1):142-156
pubmed: 28017613
Cancer Discov. 2014 Mar;4(3):362-75
pubmed: 24346116
Clin Pharmacokinet. 2018 Sep;57(9):1185-1198
pubmed: 29333561
Cell. 2013 Jan 31;152(3):519-31
pubmed: 23374347
Cancer Cell. 2018 Sep 10;34(3):361-378
pubmed: 30216189
Cell. 2015 Feb 26;160(5):977-989
pubmed: 25723171
J Biol Chem. 2005 Dec 30;280(52):42960-70
pubmed: 16219766
Mol Cell Biol. 2008 Sep;28(17):5391-402
pubmed: 18573879
Cell. 2014 Dec 18;159(7):1497-509
pubmed: 25525872
N Engl J Med. 2016 Jan 28;374(4):311-22
pubmed: 26639348
Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):E6875-E6883
pubmed: 28761001
Brain. 2003 Jan;126(Pt 1):5-19
pubmed: 12477693
Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9683-7
pubmed: 11504943
J Neurosci. 2008 Mar 19;28(12):3051-9
pubmed: 18354008
Proc Natl Acad Sci U S A. 2013 Mar 12;110(11):E986-95
pubmed: 23404709
Cell Death Differ. 2017 Sep;24(9):1598-1608
pubmed: 28574506
Science. 2011 Nov 25;334(6059):1129-33
pubmed: 22033517
Science. 2018 Feb 23;359(6378):
pubmed: 29472455
Cancer Cell. 2002 Sep;2(3):183-92
pubmed: 12242151
Cell. 1998 Oct 2;95(1):55-66
pubmed: 9778247
Sci Signal. 2014 Dec 23;7(357):ra122
pubmed: 25538080
Cell Growth Differ. 1997 Jun;8(6):643-53
pubmed: 9185998
J Immunol. 2003 Jan 1;170(1):430-7
pubmed: 12496428
Cell Cycle. 2006 Aug;5(15):1616-20
pubmed: 16880745
J Biol Chem. 1995 Apr 21;270(16):9378-83
pubmed: 7721861
Nature. 2012 Nov 1;491(7422):109-13
pubmed: 23041929
Cold Spring Harb Perspect Biol. 2013 Sep 01;5(9):
pubmed: 24003207
Neuron. 1996 Sep;17(3):401-11
pubmed: 8816704
Nat Rev Mol Cell Biol. 2014 Jan;15(1):49-63
pubmed: 24355989
Nat Microbiol. 2016 Feb 24;1:15034
pubmed: 27572165
Mol Cell Biol. 2001 Jul;21(14):4725-36
pubmed: 11416148
Neuron. 2003 Jun 19;38(6):899-914
pubmed: 12818176
Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13069-74
pubmed: 20615981
J Virol. 1994 Sep;68(9):5602-12
pubmed: 7520093
Cell Death Dis. 2013 Jun 27;4:e689
pubmed: 23807218
Biochem Biophys Res Commun. 2017 Jan 15;482(3):459-469
pubmed: 28212732
Immunity. 2010 Jun 25;32(6):754-65
pubmed: 20620942
Cell Death Differ. 2000 Jun;7(6):556-65
pubmed: 10822279
Blood. 2000 Aug 15;96(4):1438-42
pubmed: 10942389
Lancet. 2006 Dec 16;368(9553):2167-78
pubmed: 17174709
J Biol Chem. 2002 Aug 16;277(33):30128-36
pubmed: 12058036
Science. 1999 Nov 26;286(5445):1735-8
pubmed: 10576740
J Clin Invest. 1998 May 1;101(9):1992-9
pubmed: 9576764
Am J Clin Pathol. 2005 Apr;123(4):562-70
pubmed: 15743744
Int Rev Cell Mol Biol. 2017;328:163-196
pubmed: 28069133
Gut. 1999 Apr;44(4):456-62
pubmed: 10075950
PLoS One. 2008 Jun 18;3(6):e2455
pubmed: 18560593
Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):261-6
pubmed: 24363325
Cell. 2011 Nov 11;147(4):742-58
pubmed: 22078876
Cancer Cell. 2016 Dec 12;30(6):834-835
pubmed: 27960083
Crit Care. 2005 Feb;9(1):66-75
pubmed: 15693986
Cell. 1993 Nov 19;75(4):653-60
pubmed: 8242741
Exp Cell Res. 2000 Apr 10;256(1):42-9
pubmed: 10739650
Proc Natl Acad Sci U S A. 2007 May 8;104(19):8161-6
pubmed: 17483459
Semin Radiat Oncol. 2010 Jan;20(1):12-20
pubmed: 19959027
Cell. 1991 Nov 29;67(5):889-99
pubmed: 1959134
Blood. 2010 Jan 21;115(3):570-80
pubmed: 19965678
Cell Death Differ. 2008 Mar;15(3):580-8
pubmed: 18084238
Cell. 2014 Dec 18;159(7):1549-62
pubmed: 25525874
Cancer Cell. 2008 Dec 9;14(6):447-57
pubmed: 19061836
Biochem J. 2016 Apr 15;473(8):1073-83
pubmed: 26916338
Front Oncol. 2017 Apr 26;7:78
pubmed: 28491820
Curr Treat Options Cardiovasc Med. 2018 Mar 20;20(4):31
pubmed: 29556748
Mol Cell. 2015 Mar 5;57(5):860-872
pubmed: 25702873
Cancer Res. 2007 Dec 15;67(24):11867-75
pubmed: 18089817
J Biol Chem. 2005 Jul 1;280(26):24315-21
pubmed: 15851483
Blood. 2008 Feb 15;111(4):2300-9
pubmed: 18056841
Cell Death Differ. 2018 Jan;25(1):65-80
pubmed: 29149100
Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5663-8
pubmed: 19293378
Cell Rep. 2016 Dec 20;17(12):3347-3358
pubmed: 28009301
Science. 1995 Mar 10;267(5203):1506-10
pubmed: 7878471
FEBS J. 2016 Oct;283(19):3523-3533
pubmed: 26996748
IUBMB Life. 2008 Jun;60(6):390-7
pubmed: 18425793
J Immunol. 1999 Jul 15;163(2):1081-90
pubmed: 10395708
Fetal Diagn Ther. 2018;43(1):1-11
pubmed: 28586779
Nature. 2008 Oct 23;455(7216):1076-81
pubmed: 18948948
J Commun Disord. 1996 Nov-Dec;29(6):447-68; quiz 468-9
pubmed: 8956102
Front Cell Dev Biol. 2018 Feb 13;6:13
pubmed: 29497611
Int Rev Cell Mol Biol. 2019;342:27-71
pubmed: 30635093
Blood. 2011 Jun 30;117(26):7145-54
pubmed: 21562047
Cell. 2018 May 17;173(5):1217-1230.e17
pubmed: 29775594
Cancer Res. 2012 May 15;72(10):2565-77
pubmed: 22589275
Semin Cell Dev Biol. 2017 Dec;72:152-162
pubmed: 28396106
Sci Signal. 2010 Oct 26;3(145):re8
pubmed: 20978240
Cell. 2012 Oct 12;151(2):344-55
pubmed: 23063124
Mol Cell. 2001 Sep;8(3):613-21
pubmed: 11583623
Front Cell Neurosci. 2017 Aug 23;11:248
pubmed: 28878624
Cancer Discov. 2017 Dec;7(12):1376-1393
pubmed: 29146569
Cell. 2018 Apr 5;173(2):499-514.e23
pubmed: 29576454
J Mol Med (Berl). 2014 Mar;92(3):227-37
pubmed: 24477766
Cancer Cell. 2007 Aug;12(2):171-85
pubmed: 17692808
Br J Cancer. 2015 Mar 17;112(6):957-62
pubmed: 25742467
Stroke. 2009 May;40(5):e331-9
pubmed: 19182083
Biochim Biophys Acta. 2014 Sep;1843(9):2100-13
pubmed: 24927885
Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9571-6
pubmed: 8790371
J Neurotrauma. 2000 Oct;17(10):927-38
pubmed: 11063058
Nat Cell Biol. 2006 Dec;8(12):1348-58
pubmed: 17115033
Cell Chem Biol. 2017 Apr 20;24(4):493-506.e5
pubmed: 28392146
J Biol Chem. 2006 Apr 21;281(16):11250-9
pubmed: 16436379
Science. 1995 Oct 6;270(5233):96-9
pubmed: 7569956
Blood. 2011 Sep 29;118(13):3579-90
pubmed: 21772052
Cancer Cell. 2006 May;9(5):351-65
pubmed: 16697956
Mol Cell. 2000 Dec;6(6):1389-99
pubmed: 11163212
Genes Dev. 2000 Aug 15;14(16):2060-71
pubmed: 10950869
Curr Opin Genet Dev. 2010 Feb;20(1):87-90
pubmed: 20006486
Mol Cell. 2018 Mar 1;69(5):729-743.e7
pubmed: 29499131
Int J Dev Biol. 2007;51(5):415-23
pubmed: 17616931
Cancer Res. 2014 Jun 1;74(11):3146-56
pubmed: 24675361
Dev Neurosci. 2013;35(2-3):88-101
pubmed: 23445938
Nature. 1995 May 4;375(6526):81-3
pubmed: 7536901
Semin Radiat Oncol. 2010 Jan;20(1):58-66
pubmed: 19959032
Dev Cell. 2010 May 18;18(5):802-13
pubmed: 20493813
Prog Neurobiol. 2014 Jan;112:24-49
pubmed: 24211851
Genes Dev. 1999 Feb 15;13(4):382-7
pubmed: 10049353
Curr Mol Med. 2008 Mar;8(2):102-18
pubmed: 18336291
Viruses. 2017 Oct 27;9(11):
pubmed: 29077026
Invest New Drugs. 2014 Oct;32(5):976-84
pubmed: 24894650
Cell. 2002 Apr;109 Suppl:S97-107
pubmed: 11983156
Genes Dev. 2016 Apr 15;30(8):973-88
pubmed: 27056669
Mol Cell. 2013 Sep 26;51(6):751-65
pubmed: 24074954
Cell Death Differ. 2016 Jan;23(1):41-51
pubmed: 26045049
Proc Natl Acad Sci U S A. 1995 May 9;92(10):4397-401
pubmed: 7753817
Nat Rev Cancer. 2013 Jul;13(7):455-65
pubmed: 23783119
Cell Death Dis. 2014 Jan 16;5:e996
pubmed: 24434519
Nat Cell Biol. 2018 Apr;20(4):413-421
pubmed: 29531308
Hum Mol Genet. 2009 Nov 15;18(22):4317-28
pubmed: 19679562
J Immunol. 1996 Mar 15;156(6):2282-93
pubmed: 8690919
Eur Surg Res. 2002 Jan-Apr;34(1-2):37-41
pubmed: 11867899
Brain Struct Funct. 2010 Mar;214(2-3):111-26
pubmed: 20091183
Cell Death Differ. 2003 Jun;10(6):740-8
pubmed: 12761582
Brain Res. 1998 Jan 12;780(2):260-9
pubmed: 9507158
Biochemistry. 2007 Feb 13;46(6):1503-10
pubmed: 17279615
Antioxid Redox Signal. 2007 Aug;9(8):1059-96
pubmed: 17571960
J Neurosci. 2013 Nov 13;33(46):18098-108
pubmed: 24227720
J Mol Cell Biol. 2017 Apr 1;9(2):154-165
pubmed: 27927748
Nat Struct Mol Biol. 2013 May;20(5):589-97
pubmed: 23604079
Nature. 2016 Jul 27;535(7613):551-5
pubmed: 27466127
Int J Radiat Biol. 2005 Jul;81(7):545-54
pubmed: 16263658
J Biol Chem. 2004 May 14;279(20):21085-95
pubmed: 14766748
Cancer Cell. 2006 Nov;10(5):375-88
pubmed: 17097560
J Cereb Blood Flow Metab. 2007 Feb;27(2):316-26
pubmed: 16736044
Nat Rev Rheumatol. 2016 Jul;12(7):376
pubmed: 27225304
Blood. 2010 Apr 22;115(16):3258-68
pubmed: 20185587
Cell. 2007 Mar 23;128(6):1173-86
pubmed: 17382885
Mol Biol Cell. 2012 Jun;23(12):2240-52
pubmed: 22535522
J Virol. 2001 Aug;75(16):7637-50
pubmed: 11462036
Dev Biol. 2000 Feb 15;218(2):248-58
pubmed: 10656767
Philos Trans R Soc Lond B Biol Sci. 2010 May 27;365(1546):1501-15
pubmed: 20403866
J Cereb Blood Flow Metab. 2002 Apr;22(4):420-30
pubmed: 11919513
Cell Death Differ. 2010 Oct;17(10):1613-23
pubmed: 20395960
Cell Death Differ. 1998 Oct;5(10):847-57
pubmed: 10203688
Proc Natl Acad Sci U S A. 1991 Oct 1;88(19):8661-5
pubmed: 1924327
Nat Rev Cancer. 2009 Jul;9(7):501-7
pubmed: 19550425
Cancer Discov. 2017 Feb;7(2):156-164
pubmed: 27986708
Exp Mol Med. 2015 Jan 23;47:e130
pubmed: 25613727
Prog Neuropsychopharmacol Biol Psychiatry. 2003 Apr;27(2):255-65
pubmed: 12657365
Nat Rev Immunol. 2017 Jun;17(6):363-375
pubmed: 28393922
Cell. 2000 Jan 7;100(1):57-70
pubmed: 10647931
Cell Death Differ. 2018 Jan;25(1):3-6
pubmed: 29227986
Biol Chem. 2016 Jul 1;397(7):671-8
pubmed: 26910743
Sci Transl Med. 2015 Mar 18;7(279):279ra40
pubmed: 25787766
J Cell Biol. 2007 Apr 23;177(2):277-87
pubmed: 17452531
Cell. 2018 Apr 5;173(2):291-304.e6
pubmed: 29625048
Nature. 2003 Dec 11;426(6967):671-6
pubmed: 14668867
Dig Dis Sci. 2011 Apr;56(4):999-1006
pubmed: 20927590
Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5121-6
pubmed: 17360363
J Biol Chem. 2014 Jan 3;289(1):89-99
pubmed: 24265320
Oncogene. 2007 Nov 1;26(50):7067-80
pubmed: 17496930
Trends Cell Biol. 2013 Dec;23(12):612-9
pubmed: 24060597
Mol Cell. 2005 Feb 18;17(4):525-35
pubmed: 15721256
Methods. 2013 Jun 1;61(2):156-64
pubmed: 23607990
Front Cell Infect Microbiol. 2014 Mar 05;4:31
pubmed: 24634891
J Clin Invest. 2010 Oct;120(10):3673-9
pubmed: 20890041
Nat Cell Biol. 2012 Apr 29;14(6):575-83
pubmed: 22544066
Mol Biol Cell. 2012 Jan;23(1):1-6
pubmed: 22210845
Cell Death Differ. 2018 Jan;25(1):46-55
pubmed: 29053143
Cell. 2016 Jun 16;165(7):1560
pubmed: 27315468
Nature. 2002 Oct 10;419(6907):634-7
pubmed: 12374983
Nature. 2014 Mar 27;507(7493):448-54
pubmed: 24670762
J Alzheimers Dis. 2014;42 Suppl 3:S125-52
pubmed: 25056458
Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2432-7
pubmed: 12591950
Nature. 1992 Mar 26;356(6367):314-7
pubmed: 1372394
Oxid Med Cell Longev. 2015;2015:346783
pubmed: 26090071
Cancer Res. 1996 Oct 15;56(20):4610-3
pubmed: 8840972
Oncogene. 2013 May 2;32(18):2304-14
pubmed: 22710714
Nat Immunol. 2003 Mar;4(3):255-60
pubmed: 12577054
Front Neuroanat. 2014 Dec 15;8:155
pubmed: 25565980
CA Cancer J Clin. 2017 Jan;67(1):7-30
pubmed: 28055103
Cell. 1995 Jan 27;80(2):293-9
pubmed: 7834749
Cancer Discov. 2014 Sep;4(9):1074-87
pubmed: 24994123
Mol Med. 2001 Sep;7(9):644-55
pubmed: 11778654
Cell Death Differ. 2018 Mar;25(3):486-541
pubmed: 29362479
Cancer Res. 2000 Nov 15;60(22):6318-25
pubmed: 11103792
Cell Death Differ. 1998 Jan;5(1):107-15
pubmed: 10200451
Biotechnol Bioeng. 1994 Nov 5;44(9):1140-54
pubmed: 18623032
J Virol. 2000 Jul;74(14):6652-8
pubmed: 10864681
Gastroenterology. 2014 Oct;147(4):765-783.e4
pubmed: 25046161
Nat Rev Clin Oncol. 2013 Dec;10(12):697-710
pubmed: 24165948
Nat Immunol. 2003 May;4(5):410-5
pubmed: 12719730
Nature. 2001 Mar 1;410(6824):112-6
pubmed: 11242052
Mol Cancer Ther. 2015 Oct;14(10):2343-52
pubmed: 26206332
J Clin Invest. 2009 Feb;119(2):267-77
pubmed: 19164857
Mol Cell. 2015 Apr 16;58(2):284-96
pubmed: 25866249
Genes Dev. 2000 Jan 1;14(1):23-7
pubmed: 10640272
Am J Physiol Lung Cell Mol Physiol. 2004 Jun;286(6):L1220-7
pubmed: 14766669
Cell Death Differ. 2018 Jan;25(1):37-45
pubmed: 29099482
Front Cell Dev Biol. 2017 Feb 23;5:10
pubmed: 28280720
Apoptosis. 2010 Nov;15(11):1403-9
pubmed: 20127416
Mol Cell Biol. 2001 Nov;21(22):7653-62
pubmed: 11604501
Cell. 1992 Apr 3;69(1):119-28
pubmed: 1555236
Cell. 1985 Jul;41(3):899-906
pubmed: 3924412
J Neurosci. 1995 Nov;15(11):7727-33
pubmed: 7472523
J Neuropathol Exp Neurol. 1997 Jan;56(1):86-93
pubmed: 8990132
Cell Death Differ. 2003 Mar;10(3):365-70
pubmed: 12700636
Nature. 1990 Nov 22;348(6299):331-3
pubmed: 2250704
Blood. 2010 Jul 29;116(4):625-7
pubmed: 20410504
Cell Death Differ. 2014 Jun;21(6):956-66
pubmed: 24583641
EMBO J. 2000 Dec 1;19(23):6351-60
pubmed: 11101508