Chronic Chikungunya Virus Disease.


Journal

Current topics in microbiology and immunology
ISSN: 0070-217X
Titre abrégé: Curr Top Microbiol Immunol
Pays: Germany
ID NLM: 0110513

Informations de publication

Date de publication:
2022
Historique:
pubmed: 19 1 2019
medline: 5 2 2022
entrez: 19 1 2019
Statut: ppublish

Résumé

Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that has caused both small- and large-scale epidemics of incapacitating musculoskeletal disease across the globe. A substantial proportion of infected individuals experience debilitating arthralgia and/or arthritis that can persist in relapsing or continuous forms for months to years, an occurrence that appears independent of viral strain and outbreak location. Due to the lack of CHIKV-specific vaccine or therapeutics, treatment of chronic CHIKV disease is limited to supportive care. Although the epidemiologic and molecular mechanisms that dictate resolution or chronicity of CHIKV disease remain unclear, several risk factors and immunological responses have been implicated in the development of chronic CHIKV disease. Mounting evidence from animal models and limited case studies indicates that chronic disease is likely a result of induced autoimmunity and/or viral persistence in joint-associated tissue. Due to the global spread and explosive, often unpredictable nature of CHIKV epidemics, concerted efforts to obtain a more precise understanding of the development and maintenance of chronic CHIKV disease must be at the forefront of investigative endeavors.

Identifiants

pubmed: 30656438
doi: 10.1007/82_2018_147
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

55-80

Informations de copyright

© 2018. Springer Nature Switzerland AG.

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Auteurs

Mary K McCarthy (MK)

Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO, 80045, USA.

Bennett J J Davenport (BJJ)

Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO, 80045, USA.

Thomas E Morrison (TE)

Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO, 80045, USA. Thomas.Morrison@ucdenver.edu.

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