Turbinate-Specific IgE in Normal and Rhinitic Patients.

Adult Allergens / immunology Cross-Sectional Studies Female Humans Immunoglobulin E / analysis Male Middle Aged Nasal Mucosa / immunology ROC Curve Rhinitis / diagnosis Rhinitis, Allergic / diagnosis Skin Tests Turbinates / immunology
allergen allergic rhinitis asymptomatic immunoglobulin E inferior turbinate local allergic rhinitis nasal symptoms receiver operating curve tissue biopsy tissue sIgE

Journal

American journal of rhinology & allergy
ISSN: 1945-8932
Titre abrégé: Am J Rhinol Allergy
Pays: United States
ID NLM: 101490775

Informations de publication

Date de publication:
Mar 2019
Historique:
pubmed: 19 1 2019
medline: 10 8 2019
entrez: 19 1 2019
Statut: ppublish

Résumé

Specific immunoglobulin E (sIgE) within the nasal airway is likely to be the most ideal marker of allergic status, but little is known of the normative values in asymptomatic patients and those with rhinitis. The aim of this study was to assess the diagnostic characteristics of inferior turbinate tissue biopsy sIgE in asymptomatic and rhinitic patients. A diagnostic cross-sectional study was undertaken, involving patients who underwent inferior turbinate surgery with or without other surgical interventions. Inferior turbinate tissue biopsy was performed during surgery and was assessed for allergen sIgE (dust mite, grass [temperate or subtropical], and animal epithelium) using an automated immunoassay. Tissue sIgE was assessed among asymptomatic patients and those with nasal symptoms. Data were presented as median (interquartile range). A receiver operating curve was used to predict the diagnostic utility of turbinate tissue sIgE in determining allergic rhinitis. A total of 160 patients (41.89 ± 14.65 years, 36.9% females) were included. The median tissue sIgE concentration among the asymptomatic nonatopic group of patients was 0.09 (0.08-0.10) kUA/L and tissue sIgE > 0.10 kUA/L was determined as a positive threshold. Inferior turbinate tissue sIgE was shown to be a predictive test for allergic rhinitis (area under curve: 0.87, 95% confidence interval: 0.84-0.90) with 90% sensitivity and 89% negative predictive value. Inferior turbinate tissue biopsy sIgE is a sensitive tool to predict allergic rhinitis. The threshold value of 0.1 kUA/L corresponded well with the asymptomatic nonatopic group of patients. This method detects sIgE in the nasal mucosa and may be a useful test for allergic rhinitis in future research.

Sections du résumé

BACKGROUND BACKGROUND
Specific immunoglobulin E (sIgE) within the nasal airway is likely to be the most ideal marker of allergic status, but little is known of the normative values in asymptomatic patients and those with rhinitis.
OBJECTIVE OBJECTIVE
The aim of this study was to assess the diagnostic characteristics of inferior turbinate tissue biopsy sIgE in asymptomatic and rhinitic patients.
METHODS METHODS
A diagnostic cross-sectional study was undertaken, involving patients who underwent inferior turbinate surgery with or without other surgical interventions. Inferior turbinate tissue biopsy was performed during surgery and was assessed for allergen sIgE (dust mite, grass [temperate or subtropical], and animal epithelium) using an automated immunoassay. Tissue sIgE was assessed among asymptomatic patients and those with nasal symptoms. Data were presented as median (interquartile range). A receiver operating curve was used to predict the diagnostic utility of turbinate tissue sIgE in determining allergic rhinitis.
RESULTS RESULTS
A total of 160 patients (41.89 ± 14.65 years, 36.9% females) were included. The median tissue sIgE concentration among the asymptomatic nonatopic group of patients was 0.09 (0.08-0.10) kUA/L and tissue sIgE > 0.10 kUA/L was determined as a positive threshold. Inferior turbinate tissue sIgE was shown to be a predictive test for allergic rhinitis (area under curve: 0.87, 95% confidence interval: 0.84-0.90) with 90% sensitivity and 89% negative predictive value.
CONCLUSION CONCLUSIONS
Inferior turbinate tissue biopsy sIgE is a sensitive tool to predict allergic rhinitis. The threshold value of 0.1 kUA/L corresponded well with the asymptomatic nonatopic group of patients. This method detects sIgE in the nasal mucosa and may be a useful test for allergic rhinitis in future research.

Identifiants

DOI: 10.1177/1945892418825224 PMID: 30656948
pubmed: 30656948
doi: 10.1177/1945892418825224
doi:

Substances chimiques

Allergens 0
Immunoglobulin E 37341-29-0

Types de publication

Comparative Study Journal Article

Langues

eng

Pagination

178-183

Auteurs

Aneeza W Hamizan (AW)

1 Rhinology and Skull Base Research Group, St Vincent's Centre for Applied Medical Research, University of New South Wales, Sydney, Australia.
2 Department of Otorhinolaryngology, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.

Janet Rimmer (J)

1 Rhinology and Skull Base Research Group, St Vincent's Centre for Applied Medical Research, University of New South Wales, Sydney, Australia.
3 Upper Airway Research Group, Woolcock Institute, University of Sydney, Australia.
4 Faculty of Medicine, Notre Dame University, Sydney, Australia.
5 Sydney Medical School, University of Sydney, Sydney, Australia.

Raquel Alvarado (R)

1 Rhinology and Skull Base Research Group, St Vincent's Centre for Applied Medical Research, University of New South Wales, Sydney, Australia.

William A Sewell (WA)

6 St Vincent's Clinical School, University of New South Wales Sydney, Sydney, Australia.
7 Immunology Division, Garvan Institute, Sydney, Australia.
ORCID: 0000-0002-3586-8761

Jessica Tatersall (J)

1 Rhinology and Skull Base Research Group, St Vincent's Centre for Applied Medical Research, University of New South Wales, Sydney, Australia.

Henry P Barham (HP)

8 Sinus and Nasal Specialists of Louisiana, Baton Rouge, Louisiana.

Larry Kalish (L)

1 Rhinology and Skull Base Research Group, St Vincent's Centre for Applied Medical Research, University of New South Wales, Sydney, Australia.
5 Sydney Medical School, University of Sydney, Sydney, Australia.
9 Department of Otolaryngology, Head and Neck Surgery, Concord General Hospital, University of Sydney, Australia.

Richard J Harvey (RJ)

1 Rhinology and Skull Base Research Group, St Vincent's Centre for Applied Medical Research, University of New South Wales, Sydney, Australia.
10 Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Turbinate-Specific IgE in Normal and Rhinitic Patients.
questionsmedicales.fr › Facteurs biologiques › Antigènes › Allergènes › Turbinate-Specific IgE in Normal and Rhinitic Patients.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études transversales › Turbinate-Specific IgE in Normal and Rhinitic Patients.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Turbinate-Specific IgE in Normal and Rhinitic Patients.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Isotypes des immunoglobulines › Immunoglobuline E › Turbinate-Specific IgE in Normal and Rhinitic Patients.
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Turbinate-Specific IgE in Normal and Rhinitic Patients.
questionsmedicales.fr › Tissus › Membranes › Muqueuse › Muqueuse respiratoire › Muqueuse nasale › Turbinate-Specific IgE in Normal and Rhinitic Patients.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Courbe ROC › Turbinate-Specific IgE in Normal and Rhinitic Patients.
questionsmedicales.fr › Maladies oto-rhino-laryngologiques › Maladies du nez › Rhinite › Turbinate-Specific IgE in Normal and Rhinitic Patients.
questionsmedicales.fr › Maladies du système immunitaire › Hypersensibilité › Hypersensibilité immédiate › Hypersensibilité respiratoire › Rhinite allergique › Turbinate-Specific IgE in Normal and Rhinitic Patients.
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Tests immunologiques › Tests cutanés › Turbinate-Specific IgE in Normal and Rhinitic Patients.
questionsmedicales.fr › Appareil respiratoire › Cornets › Turbinate-Specific IgE in Normal and Rhinitic Patients.