Roles of EphA1/A2 and ephrin-A1 in cancer.
ADAM
Eph
S100A8
ephrin
metastasis
Journal
Cancer science
ISSN: 1349-7006
Titre abrégé: Cancer Sci
Pays: England
ID NLM: 101168776
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
received:
04
11
2018
revised:
20
12
2018
accepted:
28
12
2018
pubmed:
19
1
2019
medline:
9
3
2019
entrez:
19
1
2019
Statut:
ppublish
Résumé
The biological functions of the Eph/ephrin system have been intensively investigated and well documented so far since its discovery in 1987. Although the Eph/ephrin system has been implicated in pathological settings such as Alzheimer's disease and cancer, the molecular mechanism of the Eph/ephrin system in those diseases is not well understood. Especially in cancer, recent studies have demonstrated that most of Eph and ephrin are up- or down-regulated in various types of cancer, and have been implicated in tumor progression, tumor malignancy, and prognosis. However, they lack consistency and are in controversy. The localization patterns of EphA1 and EphA2 in mouse lungs are very similar, and both knockout mice showed similar phenotypes in the lungs. Ephrin-A1 that is a membrane-anchored ligand for EphAs was co-localized with EphA1 and EphA2 in lung vascular endothelial cells. We recently uncovered the molecular mechanism of ephrin-A1-induced lung metastasis by understanding the physiological function of ephrin-A1 in lungs. This review focuses on the function of EphA1, EphA2, and ephrin-A1 in tumors and an establishment of pre-metastatic microenvironment in the lungs.
Identifiants
pubmed: 30657619
doi: 10.1111/cas.13942
pmc: PMC6398892
doi:
Substances chimiques
Ephrin-A1
0
Receptor, EphA2
EC 2.7.10.1
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
841-848Subventions
Organisme : Japan Society for the Promotion of Science
ID : JP25870760
Organisme : Takeda Medical Research Foundation
Organisme : Yokoyama zaidan
Organisme : Uehara Memorial Foundation
Informations de copyright
© 2019 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.
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