Herbal dry extract BNO 1011 improves clinical and mucociliary parameters in a rabbit model of chronic rhinosinusitis.

Animals Chlorides / metabolism Chronic Disease Disease Models, Animal Mucociliary Clearance / drug effects Nasal Mucosa / drug effects Plant Extracts / therapeutic use Rabbits Rhinitis / drug therapy Sinusitis / drug therapy Treatment Outcome
chronic rhinosinusitis herbal dry extract micro optical coherence tomography mucociliary clearance rabbit model of sinusitis rabbit sinusitis sinus potential difference

Journal

International forum of allergy & rhinology
ISSN: 2042-6984
Titre abrégé: Int Forum Allergy Rhinol
Pays: United States
ID NLM: 101550261

Informations de publication

Date de publication:
06 2019
Historique:
received: 05 09 2018
revised: 22 12 2018
accepted: 27 12 2018
pubmed: 19 1 2019
medline: 26 3 2020
entrez: 19 1 2019
Statut: ppublish

Résumé

Enhancing chloride (Cl After the development of CRS in 30 New Zealand white rabbits, animals were randomly assigned to receive oral placebo (n = 10), BNO 1011 (low dose [LD], 25 mg/kg/daily) (n = 10), or BNO1011 (high dose [HD], 125 mg/kg/daily) (n = 10) for 4 weeks. Outcomes included sinus opacification (Kerschner's rabbit sinus CT grade), maxillary epithelial Cl BNO 1011 significantly cleared sinus opacification (HD = 1.21 ± 0.63, LD = 1.26 ± 0.37,) compared to placebo (4.02 ± 0.92) (p = 0.009). BNO 1011 resulted in markedly greater mean sinus PD polarization (HD = -12.23 ± 1.4 mV, LD = -12.0 ± 3.0 mV) when compared to rabbits treated with placebo (-4.1 ± 1.1 mV) (p = 0.03). ASL depth was significantly improved when treated with HD (4.08 ± 0.06 μm) and LD (4.05 ± 0.06 μm) compared to placebo (3.5 ± 0.05 μm) (post hoc analysis, p < 0.0001). Histologically, epithelial thickness (HD = 10.0 ± 0.7 μm; LD = 13.7 ± 0.9 μm; placebo = 21.1 ± 2.3 μm; p < 0.005), subepithelial thickness (HD = 63.1 ± 6.6 μm; LD = 103.2 ± 6.7 μm; placebo = 113.3 ± 6.0 μm; p < 0.001), and SMD (HD = 22.2 ± 2.9%; LD = 31.8 ± 1.1%; placebo = 43.8 ± 1.7%; p < 0.0001) were noticeably better with the HD. Herbal dry extract BNO 1011 improves radiographic, histologic, and MCC parameters in a rabbit model of CRS.

Sections du résumé

BACKGROUND
Enhancing chloride (Cl
METHODS
After the development of CRS in 30 New Zealand white rabbits, animals were randomly assigned to receive oral placebo (n = 10), BNO 1011 (low dose [LD], 25 mg/kg/daily) (n = 10), or BNO1011 (high dose [HD], 125 mg/kg/daily) (n = 10) for 4 weeks. Outcomes included sinus opacification (Kerschner's rabbit sinus CT grade), maxillary epithelial Cl
RESULTS
BNO 1011 significantly cleared sinus opacification (HD = 1.21 ± 0.63, LD = 1.26 ± 0.37,) compared to placebo (4.02 ± 0.92) (p = 0.009). BNO 1011 resulted in markedly greater mean sinus PD polarization (HD = -12.23 ± 1.4 mV, LD = -12.0 ± 3.0 mV) when compared to rabbits treated with placebo (-4.1 ± 1.1 mV) (p = 0.03). ASL depth was significantly improved when treated with HD (4.08 ± 0.06 μm) and LD (4.05 ± 0.06 μm) compared to placebo (3.5 ± 0.05 μm) (post hoc analysis, p < 0.0001). Histologically, epithelial thickness (HD = 10.0 ± 0.7 μm; LD = 13.7 ± 0.9 μm; placebo = 21.1 ± 2.3 μm; p < 0.005), subepithelial thickness (HD = 63.1 ± 6.6 μm; LD = 103.2 ± 6.7 μm; placebo = 113.3 ± 6.0 μm; p < 0.001), and SMD (HD = 22.2 ± 2.9%; LD = 31.8 ± 1.1%; placebo = 43.8 ± 1.7%; p < 0.0001) were noticeably better with the HD.
CONCLUSION
Herbal dry extract BNO 1011 improves radiographic, histologic, and MCC parameters in a rabbit model of CRS.

Identifiants

DOI: 10.1002/alr.22290 PMID: 30657641 PMC: PMC6555666
pubmed: 30657641
doi: 10.1002/alr.22290
pmc: PMC6555666
mid: NIHMS1004327
doi:

Substances chimiques

Chlorides 0
Plant Extracts 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

629-637

Subventions

Organisme : NIDDK NIH HHS
ID : P30 DK072482
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL133006
Pays : United States

Informations de copyright

© 2019 ARS-AAOA, LLC.

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Auteurs

Do-Yeon Cho (DY)

Department of Otolaryngology-Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, AL.
Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL.
ORCID: 0000-0002-5173-8959

Daniel Skinner (D)

Department of Otolaryngology-Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, AL.

Calvin Mackey (C)

Department of Otolaryngology-Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, AL.

Harold B Lampkin (HB)

Department of Otolaryngology-Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, AL.

Jeffrey Brent Elder (JB)

Department of Otolaryngology-Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, AL.

Dong Jin Lim (DJ)

Department of Otolaryngology-Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, AL.

Shaoyan Zhang (S)

Department of Otolaryngology-Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, AL.

Justin McCormick (J)

Department of Otolaryngology-Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, AL.

Guillermo J Tearney (GJ)

Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA.

Steven M Rowe (SM)

Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL.
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL.
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL.
Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL.

Bradford A Woodworth (BA)

Department of Otolaryngology-Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, AL.
Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL.
ORCID: 0000-0003-3292-9167

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Herbal dry extract BNO 1011 improves clinical...
questionsmedicales.fr › Produits chimiques inorganiques › Électrolytes › Ions › Anions › Chlorures › Herbal dry extract BNO 1011 improves clinical...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie chronique › Herbal dry extract BNO 1011 improves clinical...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Herbal dry extract BNO 1011 improves clinical...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques respiratoires › Clairance mucociliaire › Herbal dry extract BNO 1011 improves clinical...
questionsmedicales.fr › Tissus › Membranes › Muqueuse › Muqueuse respiratoire › Muqueuse nasale › Herbal dry extract BNO 1011 improves clinical...
questionsmedicales.fr › Préparations pharmaceutiques › Extraits de plantes › Herbal dry extract BNO 1011 improves clinical...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Lagomorpha › Lapins › Herbal dry extract BNO 1011 improves clinical...
questionsmedicales.fr › Maladies oto-rhino-laryngologiques › Maladies du nez › Rhinite › Herbal dry extract BNO 1011 improves clinical...
questionsmedicales.fr › Maladies oto-rhino-laryngologiques › Maladies du nez › Maladies des sinus › Sinusite › Herbal dry extract BNO 1011 improves clinical...
questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Qualité des soins de santé › Mécanismes d'évaluation des soins de santé › Évaluation des résultats et des processus en soins de santé › Évaluation de résultat (soins) › Résultat thérapeutique › Herbal dry extract BNO 1011 improves clinical...