Chronotherapies for Parkinson's disease.
Chronobiology
Circadian system
Exercise
Light therapy
Non-motor symptoms
Sleep
Journal
Progress in neurobiology
ISSN: 1873-5118
Titre abrégé: Prog Neurobiol
Pays: England
ID NLM: 0370121
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
25
06
2018
revised:
18
11
2018
accepted:
14
01
2019
pubmed:
19
1
2019
medline:
10
3
2020
entrez:
19
1
2019
Statut:
ppublish
Résumé
Parkinson's disease (PD) is the second-most common progressive neurodegenerative disorder. Although the clinical diagnosis of PD is still based on its cardinal motor dysfunctions, several non-motor symptoms (NMS) have been established as integral part of the disease. Unlike motor disorders, development of therapies against NMS are still challenging and remain a critical unmet clinical need. During the last decade, several studies have characterised the molecular, physiological and behavioural alterations of the circadian system in PD patients. As a consequence, and given the ubiquitous nature of circadian rhythms in the entire organism, the biological clock has emerged as a potential therapeutic target to ease suffering from both motor and NMS in PD patients. Here we discuss the emerging field of using bright light, physical exercise and melatonin as chronotherapeutic tools to alleviate motor disorders, sleep/wake alterations, anxiety and depression in PD patients. We also highlight the potential of these readily available therapies to improve the general quality of life and wellbeing of PD patients. Finally, we provide specific data- and mechanisms-driven recommendations that might help improve the therapeutic benefit of light and physical exercise in PD patients.
Identifiants
pubmed: 30658126
pii: S0301-0082(18)30099-6
doi: 10.1016/j.pneurobio.2019.01.002
pmc: PMC6377295
mid: NIHMS1519137
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
16-27Subventions
Organisme : NINDS NIH HHS
ID : R01 NS099055
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.
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