2017 McDonald criteria for multiple sclerosis: Earlier diagnosis with reduced specificity?

Adult Disease Progression Early Diagnosis Female Humans Male Middle Aged Multiple Sclerosis / cerebrospinal fluid Practice Guidelines as Topic / standards Retrospective Studies Sensitivity and Specificity

Journal

Multiple sclerosis and related disorders
ISSN: 2211-0356
Titre abrégé: Mult Scler Relat Disord
Pays: Netherlands
ID NLM: 101580247

Informations de publication

Date de publication:
Apr 2019
Historique:
received: 24 10 2018
revised: 04 12 2018
accepted: 02 01 2019
pubmed: 19 1 2019
medline: 17 7 2019
entrez: 19 1 2019
Statut: ppublish

Résumé

McDonald criteria for multiple sclerosis (MS) diagnosis were revised in 2017. Aim of our study was to evaluate and compare the sensitivity and specificity of 2017 and 2010 McDonald criteria in patients presenting with an initial demyelinating event (IDE). We retrospectively identified patients with an IDE and collected clinical, MRI and CSF data in order to demonstrate fulfilment of 2010 and 2017 McDonald criteria. 2017 McDonald criteria showed 100% (86.8-100%) sensitivity and 13.8% (3.9-31.7%) specificity. 2017 McDonald criteria appear to have higher sensitivity but reduced specificity compared to 2010 McDonald criteria.

Sections du résumé

BACKGROUND BACKGROUND
McDonald criteria for multiple sclerosis (MS) diagnosis were revised in 2017.
OBJECTIVE OBJECTIVE
Aim of our study was to evaluate and compare the sensitivity and specificity of 2017 and 2010 McDonald criteria in patients presenting with an initial demyelinating event (IDE).
METHODS METHODS
We retrospectively identified patients with an IDE and collected clinical, MRI and CSF data in order to demonstrate fulfilment of 2010 and 2017 McDonald criteria.
RESULTS RESULTS
2017 McDonald criteria showed 100% (86.8-100%) sensitivity and 13.8% (3.9-31.7%) specificity.
CONCLUSION CONCLUSIONS
2017 McDonald criteria appear to have higher sensitivity but reduced specificity compared to 2010 McDonald criteria.

Identifiants

DOI: 10.1016/j.msard.2019.01.008 PMID: 30658260
pubmed: 30658260
pii: S2211-0348(19)30009-4
doi: 10.1016/j.msard.2019.01.008
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

23-25

Informations de copyright

Copyright © 2019 Elsevier B.V. All rights reserved.

Auteurs

Francesca Gobbin (F)

Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona and Neurology Unit B, Azienda Ospedaliera Universitaria Integrata Verona, Piazzale L.A. Scuro, 10 37134 Verona, Italy. Electronic address: francescagobbin@gmail.com.

Mattia Zanoni (M)

Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona and Neurology Unit B, Azienda Ospedaliera Universitaria Integrata Verona, Piazzale L.A. Scuro, 10 37134 Verona, Italy.

Antonio Marangi (A)

Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona and Neurology Unit B, Azienda Ospedaliera Universitaria Integrata Verona, Piazzale L.A. Scuro, 10 37134 Verona, Italy.

Riccardo Orlandi (R)

Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona and Neurology Unit B, Azienda Ospedaliera Universitaria Integrata Verona, Piazzale L.A. Scuro, 10 37134 Verona, Italy.

Laura Crestani (L)

GPI SpA, Verona, Italy.

Maria Donata Benedetti (MD)

Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona and Neurology Unit B, Azienda Ospedaliera Universitaria Integrata Verona, Piazzale L.A. Scuro, 10 37134 Verona, Italy.

Alberto Gajofatto (A)

Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona and Neurology Unit B, Azienda Ospedaliera Universitaria Integrata Verona, Piazzale L.A. Scuro, 10 37134 Verona, Italy.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › 2017 McDonald criteria for multiple sclerosis:...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Évolution de la maladie › 2017 McDonald criteria for multiple sclerosis:...
questionsmedicales.fr › Diagnostic › Diagnostic précoce › 2017 McDonald criteria for multiple sclerosis:...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › 2017 McDonald criteria for multiple sclerosis:...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › 2017 McDonald criteria for multiple sclerosis:...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Maladies auto-immunes du système nerveux › Maladies démyélinisantes auto-immunes du SNC › Sclérose en plaques › 2017 McDonald criteria for multiple sclerosis:...
questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Assurance de la qualité des soins de santé › Recommandations comme sujet › Guides de bonnes pratiques cliniques comme sujet › 2017 McDonald criteria for multiple sclerosis:...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › 2017 McDonald criteria for multiple sclerosis:...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Sensibilité et spécificité › 2017 McDonald criteria for multiple sclerosis:...