Antiviral activity of itraconazole against type I feline coronavirus infection.
Journal
Veterinary research
ISSN: 1297-9716
Titre abrégé: Vet Res
Pays: England
ID NLM: 9309551
Informations de publication
Date de publication:
18 Jan 2019
18 Jan 2019
Historique:
received:
18
09
2018
accepted:
07
01
2019
entrez:
20
1
2019
pubmed:
20
1
2019
medline:
30
1
2019
Statut:
epublish
Résumé
Feline coronaviruses (FCoVs) are the causative agents of severe systemic disease (feline infectious peritonitis: FIP) in domestic and wild cats. FCoVs have been classified into serotypes I and II. Type I FCoV is the dominant serotype (approximately 70-90%) worldwide. Therefore, it is necessary to provide antiviral agents for type I FCoV infection. In this study, we demonstrated that itraconazole (ICZ), practically used for fungal infections in cats, inhibits the type I FCoV infection. ICZ also exhibited antiviral effect in cells after viral infection, suggesting that ICZ could potentially be used as a therapeutic.
Identifiants
pubmed: 30658691
doi: 10.1186/s13567-019-0625-3
pii: 10.1186/s13567-019-0625-3
pmc: PMC6339390
doi:
Substances chimiques
Antifungal Agents
0
Antiviral Agents
0
Itraconazole
304NUG5GF4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5Subventions
Organisme : Japan Society for the Promotion of Science
ID : JP16H05039
Références
Clin Infect Dis. 1999 May;28(5):1049-56
pubmed: 10452633
J Vet Med Sci. 1992 Jun;54(3):557-62
pubmed: 1322718
J Gen Virol. 2003 Oct;84(Pt 10):2735-44
pubmed: 13679608
Clin Diagn Lab Immunol. 2005 Oct;12(10):1209-15
pubmed: 16210485
Vet Microbiol. 1991 Jun;28(1):13-24
pubmed: 1653482
Antiviral Res. 2013 Aug;99(2):100-7
pubmed: 23648708
Vet J. 2014 Aug;201(2):133-41
pubmed: 24857253
Autophagy. 2014 Jul;10(7):1241-55
pubmed: 24905460
Trends Microbiol. 2014 Nov;22(11):642-7
pubmed: 25037114
BMC Vet Res. 2014 Aug 15;10:186
pubmed: 25123112
Cell Rep. 2015 Feb 3;10(4):600-15
pubmed: 25640182
Arch Virol. 2015 May;160(5):1163-70
pubmed: 25701212
Methods Mol Biol. 2015;1282:33-9
pubmed: 25720468
Arch Virol. 2016 Jan;161(1):125-33
pubmed: 26514843
PLoS Pathog. 2016 Mar 30;12(3):e1005531
pubmed: 27027316
Adv Virus Res. 2016;96:193-218
pubmed: 27712624
Proc Natl Acad Sci U S A. 2017 Jan 3;114(1):89-94
pubmed: 27994139
Antimicrob Agents Chemother. 1988 Jan;32(1):1-8
pubmed: 2831809
Antiviral Res. 2017 Sep;145:96-102
pubmed: 28780424
Virology. 2018 Apr;517:108-121
pubmed: 29329682
J Vet Intern Med. 1995 Jan-Feb;9(1):39-42
pubmed: 7891361
Am J Vet Res. 1997 Aug;58(8):872-7
pubmed: 9256973