Study of biofilm formation and antibiotic resistance pattern of gram-negative Bacilli among the clinical isolates at BPKIHS, Dharan.
Acinetobacter
/ drug effects
Anti-Bacterial Agents
Bacterial Proteins
/ metabolism
Biofilms
/ drug effects
Drug Resistance, Microbial
/ drug effects
Escherichia coli
/ drug effects
Gram-Negative Bacteria
/ classification
Gram-Negative Bacterial Infections
/ drug therapy
Humans
Microbial Sensitivity Tests
Nepal
beta-Lactamases
/ metabolism
Biofilm
Extended-spectrum beta-lactamases
Gram-negative bacilli
Metallo-beta-lactamases
Multi-drug resistant
Journal
BMC research notes
ISSN: 1756-0500
Titre abrégé: BMC Res Notes
Pays: England
ID NLM: 101462768
Informations de publication
Date de publication:
18 Jan 2019
18 Jan 2019
Historique:
received:
01
11
2018
accepted:
14
01
2019
entrez:
20
1
2019
pubmed:
20
1
2019
medline:
30
4
2019
Statut:
epublish
Résumé
Gram-negative bacilli are the common causative agents for community-acquired, nosocomial and opportunistic infections. The recent upsurge of biofilm, as well as beta-lactamases producing strains, have synergistically led to the extensive dissemination of multi-drug resistant gram-negative bacilli. This study was carried out with an intention to detect the biofilm formation by gram-negative bacilli and determine their antibiogram along with the detection of extended-spectrum beta-lactamases (ESBLs) and metallo-beta-lactamases (MBLs) production. Among 314 isolates, Escherichia coli (38%) were the predominant isolates followed by Acinetobacter spp. (20%), Klebsiella spp. (16%), and Pseudomonas spp. (12%). Overall, 197 (62.73%) of isolates were biofilm positive. 84 (26.75%) and 51 (16.24%) were confirmed as ESBL and MBL producers respectively. The association between MBL production and biofilm formation was statistically significant (χ
Identifiants
pubmed: 30658694
doi: 10.1186/s13104-019-4084-8
pii: 10.1186/s13104-019-4084-8
pmc: PMC6339267
doi:
Substances chimiques
Anti-Bacterial Agents
0
Bacterial Proteins
0
beta-Lactamases
EC 3.5.2.6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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