Normative pattern and determinants of outer retinal thickness in an Asian population: the Singapore Epidemiology of Eye Diseases Study.
epidemiology
imaging
retina
Journal
The British journal of ophthalmology
ISSN: 1468-2079
Titre abrégé: Br J Ophthalmol
Pays: England
ID NLM: 0421041
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
31
08
2018
revised:
13
11
2018
accepted:
19
11
2018
pubmed:
20
1
2019
medline:
21
3
2020
entrez:
20
1
2019
Statut:
ppublish
Résumé
To evaluate the distribution and determinants of outer retinal thickness in eyes without retinal diseases, using spectral-domain optical coherence tomography (SD-OCT). Participants were recruited from the Singapore Epidemiology of Eye Diseases Study, a population-based study among Chinese, Malays and Indians in Singapore. A total of 5333 participants underwent SD-OCT imaging in which a 6×6 mm 7444 eyes from 4454 participants were included in final analysis. Of them, mean age was 58.4 years (SD 8.3), and 2294 (51.5%) were women. Women (121.0±8.1 µm) had thinner average outer retinal thickness than men (125.6±8.2 µm) (p<0.001). Malays (121.4±8.7 µm) had thinner average outer retinal thickness than Indians (124.3±8.6 µm) and Chinese (123.7±7.9 µm) (both p<0.001). In multivariable models, thinner average outer retinal thickness was associated with older age (per decade, β=-1.02, p<0.001), hypertension (β=-0.59, p=0.029), diabetes (β=-0.73, p=0.013), chronic kidney disease (β=-1.25, p=0.017), longer axial length (per mm, β=-0.76, p<0.001), flatter corneal curvature (per mm, β=-2.00, p<0.001) and higher signal strength (β=-1.46, p<0.001). In this large sample of Asian population, we provided normative SD-OCT data on outer retinal thickness in eyes without retinal diseases. Women had thinner outer retina than men. For the first time, these findings provide fundamental knowledge on normative profile of outer retinal thickness in Asians.
Sections du résumé
BACKGROUND/AIMS
To evaluate the distribution and determinants of outer retinal thickness in eyes without retinal diseases, using spectral-domain optical coherence tomography (SD-OCT).
METHODS
Participants were recruited from the Singapore Epidemiology of Eye Diseases Study, a population-based study among Chinese, Malays and Indians in Singapore. A total of 5333 participants underwent SD-OCT imaging in which a 6×6 mm
RESULTS
7444 eyes from 4454 participants were included in final analysis. Of them, mean age was 58.4 years (SD 8.3), and 2294 (51.5%) were women. Women (121.0±8.1 µm) had thinner average outer retinal thickness than men (125.6±8.2 µm) (p<0.001). Malays (121.4±8.7 µm) had thinner average outer retinal thickness than Indians (124.3±8.6 µm) and Chinese (123.7±7.9 µm) (both p<0.001). In multivariable models, thinner average outer retinal thickness was associated with older age (per decade, β=-1.02, p<0.001), hypertension (β=-0.59, p=0.029), diabetes (β=-0.73, p=0.013), chronic kidney disease (β=-1.25, p=0.017), longer axial length (per mm, β=-0.76, p<0.001), flatter corneal curvature (per mm, β=-2.00, p<0.001) and higher signal strength (β=-1.46, p<0.001).
CONCLUSION
In this large sample of Asian population, we provided normative SD-OCT data on outer retinal thickness in eyes without retinal diseases. Women had thinner outer retina than men. For the first time, these findings provide fundamental knowledge on normative profile of outer retinal thickness in Asians.
Identifiants
pubmed: 30658991
pii: bjophthalmol-2018-313159
doi: 10.1136/bjophthalmol-2018-313159
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1406-1412Informations de copyright
© Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing Interests: None declared.