Research Progress of Glycyrrhizic Acid on Antiviral Activity.
Glycyrrhizic acid
HIV
antiviral effects
hepatitis virus
herpes virus
influenza virus.
Journal
Mini reviews in medicinal chemistry
ISSN: 1875-5607
Titre abrégé: Mini Rev Med Chem
Pays: Netherlands
ID NLM: 101094212
Informations de publication
Date de publication:
2019
2019
Historique:
received:
28
05
2018
revised:
29
07
2018
accepted:
09
01
2019
pubmed:
20
1
2019
medline:
7
8
2019
entrez:
20
1
2019
Statut:
ppublish
Résumé
Glycyrrhizic acid (GA), a triterpene isolated from the roots and rhizomes of licorice, named Glycyrrhiza glabra, is the principal bioactive ingredient of anti-viral, anti-inflammatory and hepatoprotective effects. GA has been used in the clinical treatment of hepatitis, bronchitis, gastric ulcer, AIDS (acquired immunodeficiency syndrome), certain cancers and skin diseases. It has a direct effect on anti-HBV (hepatitis B virus) via affecting the HBsAg (hepatitis B surface antigen) to extracellular secretion, improving liver dysfunction in patients with chronic hepatitis B, and ultimately improving the immune status of HBV. GA can significantly inhibit the proliferation of HIV, showing an immune activation. The clinical application of GA on the prevention and treatments of various diseases may derive from its numerous pharmacological properties. This review provides the summary of the antiviral effects of GA on research progress and mechanism in recent years.
Identifiants
pubmed: 30659537
pii: MRMC-EPUB-95928
doi: 10.2174/1389557519666190119111125
doi:
Substances chimiques
Antiviral Agents
0
Hepatitis B Surface Antigens
0
Glycyrrhizic Acid
6FO62043WK
Types de publication
Journal Article
Review
Langues
eng
Pagination
826-832Informations de copyright
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.