Changes in serum pepsinogen levels and their value as a predictor of treatment outcomes in children with peptic ulcer.
children
healing evaluation
peptic ulcer
serum pepsinogen
Journal
Journal of paediatrics and child health
ISSN: 1440-1754
Titre abrégé: J Paediatr Child Health
Pays: Australia
ID NLM: 9005421
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
30
05
2018
revised:
13
11
2018
accepted:
05
12
2018
pubmed:
20
1
2019
medline:
7
2
2021
entrez:
20
1
2019
Statut:
ppublish
Résumé
To investigate pepsinogen secretion from the neonatal stage to childhood and its diagnostic value for peptic ulcer (PU) in children. In this study, 2114 'healthy' children and 51 children with PUs undergoing a medical examination by gastroscopy were selected as subjects. The serum content of pepsinogen I (PGI) and serum pepsinogen II (PGII) was tested for each of the subjects using time-resolved fluorescence immunoassay, which is characterised by high sensitivity and a wide measuring range. The serum PGI and PGII levels were found to increase with age, becoming stable and similar to those of adults at the age of 16. In 51 children with PUs, PGI was 201.03 ± 30.74 ng/mL before treatment and 187.92 ± 19.86 ng/mL after treatment (P > 0.05); PGII was 17.36 ± 1.47 ng/mL before treatment and 17.20 ± 3.98 ng/mL after treatment (P > 0.05). It is difficult to establish the normal range of PG in children owing to its variance by age. However, if the normal reference range for individual age groups is known, it may still serve as a useful diagnosis system as well as a detecting indicator during the course of PU treatment. There are significant differences in PGI expression in children with PU before and after PU is cured, whereas other indicators show no differences before and after treatment.
Substances chimiques
Biomarkers
0
Pepsinogen C
61536-72-9
Pepsinogen A
9001-10-9
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1103-1106Subventions
Organisme : State Key Laboratory of Materials-Oriented Chemical Engineering
ID : KL17-11
Organisme : Wuxi Health Situation
ID : MU201427
Organisme : Innovation Capacity Development Plan of Jiangsu Province
ID : BM2018023-1
Informations de copyright
© 2019 Paediatrics and Child Health Division (The Royal Australasian College of Physicians).
Références
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