Methylmercury's chemistry: From the environment to the mammalian brain.
Exchange reaction
Methylation/demethylation
Neurotoxicity
Organomercurials
Rabenstein's Reaction
Thiol/selenol groups
Journal
Biochimica et biophysica acta. General subjects
ISSN: 1872-8006
Titre abrégé: Biochim Biophys Acta Gen Subj
Pays: Netherlands
ID NLM: 101731726
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
23
09
2018
revised:
14
12
2018
accepted:
09
01
2019
pubmed:
20
1
2019
medline:
19
5
2020
entrez:
20
1
2019
Statut:
ppublish
Résumé
Methylmercury is a neurotoxicant that is found in fish and rice. MeHg's toxicity is mediated by blockage of -SH and -SeH groups of proteins. However, the identification of MeHg's targets is elusive. Here we focus on the chemistry of MeHg in the abiotic and biotic environment. The toxicological chemistry of MeHg is complex in metazoans, but at the atomic level it can be explained by exchange reactions of MeHg bound to -S(e)H with another free -S(e)H group (R
Identifiants
pubmed: 30659885
pii: S0304-4165(19)30012-1
doi: 10.1016/j.bbagen.2019.01.006
pii:
doi:
Substances chimiques
Environmental Pollutants
0
Methylmercury Compounds
0
Nerve Tissue Proteins
0
Selenoproteins
0
Cysteine
K848JZ4886
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
129284Subventions
Organisme : NIEHS NIH HHS
ID : R01 ES020852
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.