First look into the venom of Roatan Island's critically endangered coral snake Micrurus ruatanus: Proteomic characterization, toxicity, immunorecognition and neutralization by an antivenom.
Coral snake
Micrurus ruatanus
Venomics
Journal
Journal of proteomics
ISSN: 1876-7737
Titre abrégé: J Proteomics
Pays: Netherlands
ID NLM: 101475056
Informations de publication
Date de publication:
30 04 2019
30 04 2019
Historique:
received:
16
12
2018
revised:
11
01
2019
accepted:
14
01
2019
pubmed:
20
1
2019
medline:
9
7
2020
entrez:
20
1
2019
Statut:
ppublish
Résumé
A proteomic and toxicological study of the venom from one specimen of Micrurus ruatanus, a critically endangered coral snake species endemic to Roatan Island, Honduras, was carried out. Immunorecognition and neutralization of venom lethality by an anticoral antivenom was also evaluated. Forty peaks were collected from RP-HPLC fractionation of the venom. After SDS-PAGE analysis, fifty-eight bands were examined by MALDI-TOF/TOF mass spectrometry. Micrurus ruatanus venom displayed a three-finger toxin (3FTx)-rich venom phenotype, as well as a significant amount of phospholipases A
Identifiants
pubmed: 30659935
pii: S1874-3919(19)30015-6
doi: 10.1016/j.jprot.2019.01.007
pii:
doi:
Substances chimiques
Antibodies, Neutralizing
0
Antivenins
0
Elapid Venoms
0
Reptilian Proteins
0
micrurus venom
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
177-185Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.