Chemical characterization of liposomes containing nutraceutical compounds: Tyrosol, hydroxytyrosol and oleuropein.

Acetates / administration & dosage Antioxidants / administration & dosage Catechols / administration & dosage Cells, Cultured Chondrocytes / cytology Dietary Supplements Drug Delivery Systems / methods Humans Iridoid Glucosides Iridoids / administration & dosage Liposomes / chemical synthesis Olea / chemistry Phenylethyl Alcohol / administration & dosage
Antioxidant Encapsulation efficiency Liposome Nutraceutics Oleuropein Tyrosol, hydroxytyrosol

Journal

Biophysical chemistry
ISSN: 1873-4200
Titre abrégé: Biophys Chem
Pays: Netherlands
ID NLM: 0403171

Informations de publication

Date de publication:
03 2019
Historique:
received: 09 11 2018
revised: 11 01 2019
accepted: 11 01 2019
pubmed: 20 1 2019
medline: 21 3 2019
entrez: 20 1 2019
Statut: ppublish

Résumé

Tyrosol, hydroxytyrosol and oleuropein are among the major phenolic compounds in fruits, leaves and oils from Olea europaea L. These natural antioxidants molecules revealed several beneficial effects on human health, but a low bioavailability and accessibility to targeted site. Liposomes are drug/nutraceutical delivery carriers, used for driving bioactive molecules to desired target tissues, decreasing potential side effects and protecting the encapsulated molecule from enzymatic metabolic processes. In this study, zwitterionic liposomes containing tyrosol, hydroxytyrosol and oleuropein were synthesized and characterized for their size and surface charge. Particular attention was devoted to the determination of encapsulation efficiency (EE%), quantifying the loaded Tyr, HTyr and Ole amount, by using three different techniques: direct UV spectrophotometry, High Performance Liquid Chromatography and Trolox Equivalent Antioxidant Capacity assay. The results revealed higher EE% for oleuropein. Cyto-toxicity and cyto-compatibility of liposomes were also tested on human chondrocyte cells.

Identifiants

DOI: 10.1016/j.bpc.2019.01.002 PMID: 30659995
pubmed: 30659995
pii: S0301-4622(18)30364-8
doi: 10.1016/j.bpc.2019.01.002
pii:
doi:

Substances chimiques

Acetates 0
Antioxidants 0
Catechols 0
Iridoid Glucosides 0
Iridoids 0
Liposomes 0
hydroxytyrosyl acetate 0
4-hydroxyphenylethanol 1AK4MU3SNX
oleuropein 2O4553545L
Phenylethyl Alcohol ML9LGA7468

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

25-34

Informations de copyright

Copyright © 2019 Elsevier B.V. All rights reserved.

Auteurs

Claudia Bonechi (C)

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, Siena 53100, Italy; Centre for Colloid and Surface Science (CSGI), University of Florence, Via della Lastruccia 3, Sesto Fiorentino, FI 50019, Italy. Electronic address: claudia.bonechi@unisi.it.

Alessandro Donati (A)

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, Siena 53100, Italy; Centre for Colloid and Surface Science (CSGI), University of Florence, Via della Lastruccia 3, Sesto Fiorentino, FI 50019, Italy. Electronic address: alessandro.donati@unisi.it.

Gabriella Tamasi (G)

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, Siena 53100, Italy; Centre for Colloid and Surface Science (CSGI), University of Florence, Via della Lastruccia 3, Sesto Fiorentino, FI 50019, Italy.

Alessio Pardini (A)

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, Siena 53100, Italy.

Hanzadah Rostom (H)

Centre for Colloid and Surface Science (CSGI), University of Florence, Via della Lastruccia 3, Sesto Fiorentino, FI 50019, Italy.

Gemma Leone (G)

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, Siena 53100, Italy; National Interuniversity Consortium of Materials Science and Technology (INSTM), Via G. Giusti 9, Firenze 50121, Italy.

Stefania Lamponi (S)

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, Siena 53100, Italy; National Interuniversity Consortium of Materials Science and Technology (INSTM), Via G. Giusti 9, Firenze 50121, Italy.

Marco Consumi (M)

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, Siena 53100, Italy; National Interuniversity Consortium of Materials Science and Technology (INSTM), Via G. Giusti 9, Firenze 50121, Italy.

Agnese Magnani (A)

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, Siena 53100, Italy; National Interuniversity Consortium of Materials Science and Technology (INSTM), Via G. Giusti 9, Firenze 50121, Italy. Electronic address: agnese.magnani@unisi.it.

Claudio Rossi (C)

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, Siena 53100, Italy; Centre for Colloid and Surface Science (CSGI), University of Florence, Via della Lastruccia 3, Sesto Fiorentino, FI 50019, Italy; Operative Unit, University of Siena, CampoVerde, Calabria, Italy.

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Classifications MeSH

questionsmedicales.fr › Lipides › Acides gras › Acides gras volatils › Acétates › Chemical characterization of liposomes...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Antioxydants › Chemical characterization of liposomes...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Catéchols › Chemical characterization of liposomes...
questionsmedicales.fr › Cellules › Cellules cultivées › Chemical characterization of liposomes...
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Chondrocytes › Chemical characterization of liposomes...
questionsmedicales.fr › Aliments et boissons › Aliments › Compléments alimentaires › Chemical characterization of liposomes...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › Chemical characterization of liposomes...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Chemical characterization of liposomes...
questionsmedicales.fr › Glucides › Hétérosides › Glycosides d'iridoïdes › Glucosides d'iridoïdes › Chemical characterization of liposomes...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrannes › Iridoïdes › Chemical characterization of liposomes...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomimétiques › Membrane artificielle › Liposomes › Chemical characterization of liposomes...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Lamiales › Oleaceae › Olea › Chemical characterization of liposomes...
questionsmedicales.fr › Composés chimiques organiques › Alcools › Éthanol › Alcool phénéthylique › Chemical characterization of liposomes...