Sub-picomolar quantification of PTH 1-34 in plasma by UHPLC-MS/MS after subcutaneous injection of teriparatide and identification of PTH 1-33, its degradation product.

Area Under Curve Calibration Chromatography, High Pressure Liquid Drug Stability Half-Life Healthy Volunteers Humans Immunoassay Injections, Subcutaneous Limit of Detection Peptide Fragments / blood Reproducibility of Results Tandem Mass Spectrometry Teriparatide / administration & dosage
PTH 1-33 PTH 1-34 Parathyroid hormone Pharmacokinetic Teriparatide UHPLC-MS/MS

Journal

Journal of pharmaceutical and biomedical analysis
ISSN: 1873-264X
Titre abrégé: J Pharm Biomed Anal
Pays: England
ID NLM: 8309336

Informations de publication

Date de publication:
20 Mar 2019
Historique:
received: 02 11 2018
revised: 07 01 2019
accepted: 08 01 2019
pubmed: 20 1 2019
medline: 14 6 2019
entrez: 20 1 2019
Statut: ppublish

Résumé

Teriparatide (PTH 1-34, Forsteo

Identifiants

DOI: 10.1016/j.jpba.2019.01.011 PMID: 30660035
pubmed: 30660035
pii: S0731-7085(18)32475-0
doi: 10.1016/j.jpba.2019.01.011
pii:
doi:

Substances chimiques

Peptide Fragments 0
Teriparatide 10T9CSU89I

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

205-212

Informations de copyright

Copyright © 2019 Elsevier B.V. All rights reserved.

Auteurs

Philippe J Eugster (PJ)

Service of Clinical Pharmacology, Lausanne University Hospital (CHUV), Lausanne, Switzerland. Electronic address: philippe.eugster@chuv.ch.

Haithem Chtioui (H)

Service of Clinical Pharmacology, Lausanne University Hospital (CHUV), Lausanne, Switzerland.

Adeline Herren (A)

Service of Clinical Pharmacology, Lausanne University Hospital (CHUV), Lausanne, Switzerland.

Marielle Dunand (M)

Service of Clinical Pharmacology, Lausanne University Hospital (CHUV), Lausanne, Switzerland.

Delphine Cappelle (D)

Service of Clinical Pharmacology, Lausanne University Hospital (CHUV), Lausanne, Switzerland.

Julien Bourquin (J)

Waters Corporation, Stamford Avenue, Altrincham Road, Wilmslow, SK9 4AX, United Kingdom.

Thierry Buclin (T)

Service of Clinical Pharmacology, Lausanne University Hospital (CHUV), Lausanne, Switzerland.

Eric Grouzmann (E)

Service of Clinical Pharmacology, Lausanne University Hospital (CHUV), Lausanne, Switzerland.

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Classifications MeSH

questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Aire sous la courbe › Sub-picomolar quantification of PTH 1-34 in...
questionsmedicales.fr › Techniques d'investigation › Poids et mesures › Calibrage › Sub-picomolar quantification of PTH 1-34 in...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Chromatographie › Chromatographie en phase liquide › Chromatographie en phase liquide à haute performance › Sub-picomolar quantification of PTH 1-34 in...
questionsmedicales.fr › Techniques d'investigation › Stabilité de médicament › Sub-picomolar quantification of PTH 1-34 in...
questionsmedicales.fr › Phénomènes physiques › Temps › Période › Sub-picomolar quantification of PTH 1-34 in...
questionsmedicales.fr › Personnes › Bénévoles › Volontaires sains › Sub-picomolar quantification of PTH 1-34 in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Sub-picomolar quantification of PTH 1-34 in...
questionsmedicales.fr › Techniques d'investigation › Techniques de sonde moléculaire › Dosage immunologique › Sub-picomolar quantification of PTH 1-34 in...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Injections › Injections sous-cutanées › Sub-picomolar quantification of PTH 1-34 in...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Sensibilité et spécificité › Limite de détection › Sub-picomolar quantification of PTH 1-34 in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Fragments peptidiques › Sub-picomolar quantification of PTH 1-34 in...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Reproductibilité des résultats › Sub-picomolar quantification of PTH 1-34 in...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Spectrométrie de masse en tandem › Sub-picomolar quantification of PTH 1-34 in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormone parathyroïdienne › Tériparatide › Sub-picomolar quantification of PTH 1-34 in...