Ultrasound-responsive nanobubbles for enhanced intravitreal drug migration: An ex vivo evaluation.

Animals Cattle Drug Delivery Systems / methods Fluorescent Dyes / administration & dosage Intravitreal Injections / methods Nanocapsules / administration & dosage Spectrometry, Fluorescence / methods Swine Ultrasonic Waves Vitreous Body / chemistry
Ex vivo Intravitreal drug delivery Nanobubbles Ocular drug delivery Ultrasound

Journal

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
ISSN: 1873-3441
Titre abrégé: Eur J Pharm Biopharm
Pays: Netherlands
ID NLM: 9109778

Informations de publication

Date de publication:
Mar 2019
Historique:
received: 08 11 2018
revised: 14 01 2019
accepted: 15 01 2019
pubmed: 21 1 2019
medline: 31 5 2019
entrez: 21 1 2019
Statut: ppublish

Résumé

The intravitreal route faces many challenges in rapidly and effectively reaching posterior eye pathology, with administered therapeutics experiencing non-specific distribution around and premature clearance from ocular tissues. Nanobubbles and ultrasound may improve outcomes of intravitreally administered drugs by influencing the directionality of drug-containing particle migration. In this study, we assessed the impact of trans-scleral or corneal ultrasound application on the distribution of intravitreally-injected nanobubbles. Rhodamine-tagged gas entrapped nanobubble formulations were prepared and injected into ex vivo bovine and porcine eyes and subjected to ultrasound (1 MHz, 0-2.5 W/cm

Identifiants

DOI: 10.1016/j.ejpb.2019.01.014 PMID: 30660691
pubmed: 30660691
pii: S0939-6411(18)31412-7
doi: 10.1016/j.ejpb.2019.01.014
pii:
doi:

Substances chimiques

Fluorescent Dyes 0
Nanocapsules 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

102-107

Informations de copyright

Copyright © 2019 Elsevier B.V. All rights reserved.

Auteurs

Sachin S Thakur (SS)

The University of Queensland, School of Pharmacy, Pharmacy Australia Centre of Excellence, 20 Cornwall Street, Woolloongabba, Brisbane, QLD 4102, Australia; Buchanan Ocular Therapeutics Unit, Department of Ophthalmology, New Zealand National Eye Centre, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.

Ying-Shan Chen (YS)

Buchanan Ocular Therapeutics Unit, Department of Ophthalmology, New Zealand National Eye Centre, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.

Zachary H Houston (ZH)

Centre for Advanced Imaging (CAI), Australian Institute for Bioengineering and Nanotechnology (AIBN) and ARC Centre of Excellence in Convergent BioNano Science and Technology, The University of Queensland, Brisbane, QLD 4072, Australia.

Nicholas Fletcher (N)

Centre for Advanced Imaging (CAI), Australian Institute for Bioengineering and Nanotechnology (AIBN) and ARC Centre of Excellence in Convergent BioNano Science and Technology, The University of Queensland, Brisbane, QLD 4072, Australia.

Nigel L Barnett (NL)

Clem Jones Centre for Regenerative Medicine, Faculty of Health Science & Medicine, Bond University, Gold Coast, QLD 4229, Australia; Queensland Eye Institute, 140 Melbourne Street, South Brisbane, QLD 4101, Australia; The University of Queensland, UQ Centre for Clinical Research, Building 71/918 RBWH Herston, Herston, QLD 4029, Australia.

Kristofer J Thurecht (KJ)

Centre for Advanced Imaging (CAI), Australian Institute for Bioengineering and Nanotechnology (AIBN) and ARC Centre of Excellence in Convergent BioNano Science and Technology, The University of Queensland, Brisbane, QLD 4072, Australia.

Ilva D Rupenthal (ID)

Buchanan Ocular Therapeutics Unit, Department of Ophthalmology, New Zealand National Eye Centre, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.

Harendra S Parekh (HS)

The University of Queensland, School of Pharmacy, Pharmacy Australia Centre of Excellence, 20 Cornwall Street, Woolloongabba, Brisbane, QLD 4102, Australia. Electronic address: h.parekh@uq.edu.au.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Ultrasound-responsive nanobubbles for enhanced...
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questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › Ultrasound-responsive nanobubbles for enhanced...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Indicateurs et réactifs › Luminescents › Colorants fluorescents › Ultrasound-responsive nanobubbles for enhanced...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Injections › Injections oculaires › Injections intravitréennes › Ultrasound-responsive nanobubbles for enhanced...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › Nanocapsules › Ultrasound-responsive nanobubbles for enhanced...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectrométrie de fluorescence › Ultrasound-responsive nanobubbles for enhanced...
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questionsmedicales.fr › Phénomènes physiques › Rayonnement › Rayonnement non ionisant › Son (physique) › Ondes ultrasonores › Ultrasound-responsive nanobubbles for enhanced...
questionsmedicales.fr › Organes des sens › Oeil › Segment postérieur de l'oeil › Corps vitré › Ultrasound-responsive nanobubbles for enhanced...