Quinolone hybrids and their anti-cancer activities: An overview.

Animals Antineoplastic Agents / chemistry Humans Neoplasms / drug therapy Quinolones / chemistry Structure-Activity Relationship
Anti-Cancer Hybrid compounds Quinolone Structure-activity relationship

Journal

European journal of medicinal chemistry
ISSN: 1768-3254
Titre abrégé: Eur J Med Chem
Pays: France
ID NLM: 0420510

Informations de publication

Date de publication:
01 Mar 2019
Historique:
received: 10 12 2018
revised: 07 01 2019
accepted: 08 01 2019
pubmed: 21 1 2019
medline: 22 3 2019
entrez: 21 1 2019
Statut: ppublish

Résumé

The global pandemic of drug-sensitive cancers and the increasing threat from drug-resistant cancers make an urgent need to develop more effective anti-cancer candidates. Quinolone derivatives possess promising anti-cancer activity, and some of them have already been approved to treat cancers or under clinical trials. Hybridization of quinolone with other anti-cancer pharmacophores may provide more efficient anti-cancer candidates, so quinolone hybrids worth to be investigated. In this review, the recent advances in the development of novel quinolone hybrids as potential anti-cancer agents are highlighted, and the structure-activity relationship is also discussed to provide an insight for further development of more active quinolone hybrids.

Identifiants

DOI: 10.1016/j.ejmech.2019.01.017 PMID: 30660827
pubmed: 30660827
pii: S0223-5234(19)30027-3
doi: 10.1016/j.ejmech.2019.01.017
pii:
doi:

Substances chimiques

Antineoplastic Agents 0
Quinolones 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

59-79

Informations de copyright

Copyright © 2019 Elsevier Masson SAS. All rights reserved.

Auteurs

Feng Gao (F)

Academy of Advanced Interdisciplinary Studies, Qilu University of Technology (Shandong Academy of Sciences), Jinan, PR China; School of Chemistry and Pharmaceutical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, PR China; Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, PR China. Electronic address: rggaofeng@hotmail.com.

Xia Zhang (X)

Academy of Advanced Interdisciplinary Studies, Qilu University of Technology (Shandong Academy of Sciences), Jinan, PR China.

Tengfei Wang (T)

State Key Laboratory of Biobased Material and Green Papermaking (LBMP), Qilu University of Technology (Shandong Academy of Sciences), Jinan, PR China.

Jiaqi Xiao (J)

Academy of Advanced Interdisciplinary Studies, Qilu University of Technology (Shandong Academy of Sciences), Jinan, PR China; School of Chemistry and Pharmaceutical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, PR China. Electronic address: jiaqixiao@qlu.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Quinolone hybrids and their anti-cancer...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Quinolone hybrids and their anti-cancer...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Quinolone hybrids and their anti-cancer...
questionsmedicales.fr › Tumeurs › Quinolone hybrids and their anti-cancer...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinoléines › Quinolinone › Quinolone hybrids and their anti-cancer...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Quinolone hybrids and their anti-cancer...