Spatial analysis of p63, K5 and K7 defines two groups of progenitor cells that differentially contribute to the maintenance of normal sebaceous glands, extraocular sebaceous carcinoma and benign sebaceous tumors.
Adenocarcinoma, Sebaceous
/ pathology
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
/ metabolism
Cell Differentiation
Cohort Studies
Female
Humans
Keratin-5
/ metabolism
Keratin-7
/ metabolism
Male
Membrane Proteins
/ metabolism
Middle Aged
Sebaceous Gland Neoplasms
/ pathology
Sebaceous Glands
/ cytology
Stem Cells
/ pathology
basal and luminal keratins
p63
progenitor cells
sebaceous glands
sebaceous tumors
Journal
The Journal of dermatology
ISSN: 1346-8138
Titre abrégé: J Dermatol
Pays: England
ID NLM: 7600545
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
received:
24
07
2018
accepted:
29
11
2018
pubmed:
22
1
2019
medline:
18
6
2019
entrez:
22
1
2019
Statut:
ppublish
Résumé
The histogenesis of extraocular sebaceous carcinomas is - in contrast to ocular sebaceous carcinomas - unclear, and information about the exact cellular architecture of these lesions and even of the normal sebaceous gland is still scarce. This study attempts to elucidate the histogenesis of sebaceous tumors, using multicolor immunofluorescence stainings to analyze 21 cases of sebaceous tumors (six each of extraocular sebaceous carcinoma, sebaceous adenoma and sebaceoma, and three cases of steatocystomas) and eight cases of normal sebaceous glands for p63, several keratins, androgen receptor, adipophilin, epithelial membrane antigen (EMA) and Ki-67. The data of this observational study provide evidence for the existence of two subpopulations of progenitors in normal sebaceous glands: (i) p63
Identifiants
pubmed: 30663115
doi: 10.1111/1346-8138.14765
doi:
Substances chimiques
Biomarkers, Tumor
0
CKAP4 protein, human
0
KRT5 protein, human
0
KRT7 protein, human
0
Keratin-5
0
Keratin-7
0
Membrane Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
249-258Informations de copyright
© 2019 Japanese Dermatological Association.