Computational modeling of brainstem circuits controlling locomotor frequency and gait.
central pattern generator
locomotor speed
mesencephalic locomotor region
neuroscience
none
reticular formation
spinal locomotor circuits
supraspinal
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
21 01 2019
21 01 2019
Historique:
received:
15
11
2018
accepted:
19
01
2019
pubmed:
22
1
2019
medline:
28
5
2020
entrez:
22
1
2019
Statut:
epublish
Résumé
A series of recent studies identified key structures in the mesencephalic locomotor region and the caudal brainstem of mice involved in the initiation and control of slow (exploratory) and fast (escape-type) locomotion and gait. However, the interactions of these brainstem centers with each other and with the spinal locomotor circuits are poorly understood. Previously we suggested that commissural and long propriospinal interneurons are the main targets for brainstem inputs adjusting gait (Danner et al., 2017). Here, by extending our previous model, we propose a connectome of the brainstem-spinal circuitry and suggest a mechanistic explanation of the operation of brainstem structures and their roles in controlling speed and gait. We suggest that brainstem control of locomotion is mediated by two pathways, one controlling locomotor speed via connections to rhythm generating circuits in the spinal cord and the other providing gait control by targeting commissural and long propriospinal interneurons.
Identifiants
pubmed: 30663578
doi: 10.7554/eLife.43587
pii: 43587
pmc: PMC6355193
doi:
pii:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : College of Medicine, Drexel University
ID : Edward Jekkal Muscular Dystrophy Association Fellowship
Pays : International
Organisme : NIH HHS
ID : R01NS090919
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS095366
Pays : United States
Organisme : NIH HHS
ID : R01NS095366
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS090919
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS100928
Pays : United States
Informations de copyright
© 2019, Ausborn et al.
Déclaration de conflit d'intérêts
JA, NS, VC, SD, IR No competing interests declared
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