Constitutional mislocalization of Pten drives precocious maturation in oligodendrocytes and aberrant myelination in model of autism spectrum disorder.
Animals
Autism Spectrum Disorder
/ physiopathology
Brain
/ physiopathology
Cell Differentiation
Cells, Cultured
Disease Models, Animal
Female
Male
Mice
Mutation, Missense
Myelin Proteins
/ metabolism
Neurogenesis
Neuroglia
/ cytology
Oligodendrocyte Precursor Cells
/ cytology
PTEN Phosphohydrolase
/ genetics
Journal
Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664
Informations de publication
Date de publication:
17 01 2019
17 01 2019
Historique:
received:
27
07
2018
accepted:
13
11
2018
revised:
10
11
2018
entrez:
22
1
2019
pubmed:
22
1
2019
medline:
21
5
2019
Statut:
epublish
Résumé
There is a strong genetic association between germline PTEN mutation and autism spectrum disorder (ASD), making Pten-mutant models exemplary for the study of ASD pathophysiology. We developed the Pten
Identifiants
pubmed: 30664625
doi: 10.1038/s41398-018-0364-7
pii: 10.1038/s41398-018-0364-7
pmc: PMC6341090
doi:
Substances chimiques
Myelin Proteins
0
PTEN Phosphohydrolase
EC 3.1.3.67
Pten protein, mouse
EC 3.1.3.67
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
13Subventions
Organisme : NINDS NIH HHS
ID : R01 NS096148
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM088088
Pays : United States
Références
Glia. 1997 Jan;19(1):85-90
pubmed: 8989571
Autism Res. 2010 Jun;3(3):137-41
pubmed: 20533527
Nature. 2011 Aug 10;476(7359):163-9
pubmed: 21833082
J Neurosci. 2009 May 27;29(21):6860-70
pubmed: 19474313
EMBO J. 1984 Oct;3(10):2243-7
pubmed: 6542000
Elife. 2018 Feb 20;7:
pubmed: 29461205
Mol Psychiatry. 2016 Jan;21(1):118-25
pubmed: 25754085
J Cell Biol. 1980 Jun;85(3):890-902
pubmed: 6248568
Int J Mol Sci. 2017 Mar 15;18(3):
pubmed: 28294977
Neurotherapeutics. 2015 Jul;12(3):609-19
pubmed: 25916396
J Cell Biol. 1999 Dec 13;147(6):1123-8
pubmed: 10601327
Endocr Relat Cancer. 2018 Aug;25(8):T121-T140
pubmed: 29792313
Nat Rev Neurosci. 2006 Aug;7(8):617-27
pubmed: 16858390
Cold Spring Harb Protoc. 2014 Aug 01;2014(8):813-4
pubmed: 25086024
J Neurosci Res. 1990 Nov;27(3):400-7
pubmed: 2097382
Stem Cells. 2014 Jan;32(1):313-26
pubmed: 24395742
Am J Hum Genet. 2011 Jan 7;88(1):42-56
pubmed: 21194675
Nature. 1985 Jan 17-23;313(5999):223-5
pubmed: 3969137
Development. 1994 May;120(5):1097-108
pubmed: 8026323
Hum Mol Genet. 2014 Jun 15;23(12):3212-27
pubmed: 24470394
J Neurosci. 2008 Jul 9;28(28):7174-83
pubmed: 18614687
Mol Psychiatry. 2015 Sep;20(9):1132-8
pubmed: 25288137
J Med Genet. 2005 Apr;42(4):318-21
pubmed: 15805158
Ann Neurol. 2010 Nov;68(5):703-16
pubmed: 20853437
PLoS One. 2011 May 12;6(5):e19849
pubmed: 21589880
Nature. 1978 Aug 24;274(5673):813-6
pubmed: 355894