Opening up new horizons for psychiatric genetics in the Russian Federation: moving toward a national consortium.

Biomedical Research Genome-Wide Association Study Humans Intersectoral Collaboration Mental Disorders / epidemiology Mental Health / ethnology Russia / epidemiology

Journal

Molecular psychiatry

ISSN: 1476-5578

Titre abrégé: Mol Psychiatry

Pays: England

ID NLM: 9607835

Informations de publication

Date de publication:
08 2019

Historique:

received: 11 08 2018

accepted: 31 12 2018

revised: 27 12 2018

pubmed: 22 1 2019

medline: 10 3 2020

entrez: 22 1 2019

Statut: ppublish

Résumé

We provide an overview of the recent achievements in psychiatric genetics research in the Russian Federation and present genotype-phenotype, population, epigenetic, cytogenetic, functional, ENIGMA, and pharmacogenetic studies, with an emphasis on genome-wide association studies. The genetic backgrounds of mental illnesses in the polyethnic and multicultural population of the Russian Federation are still understudied. Furthermore, genetic, genomic, and pharmacogenetic data from the Russian Federation are not adequately represented in the international scientific literature, are currently not available for meta-analyses and have never been compared with data from other populations. Most of these problems cannot be solved by individual centers working in isolation but warrant a truly collaborative effort that brings together all the major psychiatric genetic research centers in the Russian Federation in a national consortium. For this reason, we have established the Russian National Consortium for Psychiatric Genetics (RNCPG) with the aim to strengthen the power and rigor of psychiatric genetics research in the Russian Federation and enhance the international compatibility of this research.The consortium is set up as an open organization that will facilitate collaborations on complex biomedical research projects in human mental health in the Russian Federation and abroad. These projects will include genotyping, sequencing, transcriptome and epigenome analysis, metabolomics, and a wide array of other state-of-the-art analyses. Here, we discuss the challenges we face and the approaches we will take to unlock the huge potential that the Russian Federation holds for the worldwide psychiatric genetics community.

Identifiants

DOI: 10.1038/s41380-019-0354-z PMID: 30664668 PMC: PMC6756082

pubmed: 30664668

doi: 10.1038/s41380-019-0354-z

pii: 10.1038/s41380-019-0354-z

pmc: PMC6756082

doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Pagination

1099-1111

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