Test models for the evaluation of immunogenicity of protein aggregates.
Immunogenicity
In vitro models
In vivo models
Protein aggregates
Journal
International journal of pharmaceutics
ISSN: 1873-3476
Titre abrégé: Int J Pharm
Pays: Netherlands
ID NLM: 7804127
Informations de publication
Date de publication:
25 Mar 2019
25 Mar 2019
Historique:
received:
20
11
2018
revised:
08
01
2019
accepted:
09
01
2019
pubmed:
22
1
2019
medline:
14
6
2019
entrez:
22
1
2019
Statut:
ppublish
Résumé
Protein aggregates have been discussed for a long time as a potential risk factor for immunogenicity in patients. Meanwhile, many research groups have investigated the immunogenicity of differently produced aggregates using in vitro or in vivo models. Despite all knowledge gained in these studies still little is known about the mechanisms of immunogenicity and the kind of protein aggregates bearing the greatest risk for immunogenicity. The choice of a suitable test model regarding the predictability of immunogenicity of protein aggregates in humans plays a major role and influences results and conclusions substantially. In this review we will provide an overview of the test models recently used for the evaluation of immunogenicity of protein aggregates; we will discuss advantages and drawbacks regarding their usability and predictive power for immunogenicity in humans.
Identifiants
pubmed: 30665000
pii: S0378-5173(19)30049-3
doi: 10.1016/j.ijpharm.2019.01.015
pii:
doi:
Substances chimiques
Protein Aggregates
0
Proteins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
192-200Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.