Studies towards the development of a PET radiotracer for imaging of the P2Y

Allosteric Site Boron Neutron Capture Therapy / methods Brain / diagnostic imaging Fluorine Radioisotopes Phenylurea Compounds / chemical synthesis Positron-Emission Tomography / methods Radiopharmaceuticals / chemical synthesis Receptors, Purinergic P2Y1 / analysis
Brain PET tracers Hydrophilic interaction chromatography Micellar chromatography Positron emission tomography Purine P2Y(1) receptors Radiometabolites

Journal

European journal of medicinal chemistry
ISSN: 1768-3254
Titre abrégé: Eur J Med Chem
Pays: France
ID NLM: 0420510

Informations de publication

Date de publication:
01 Mar 2019
Historique:
received: 28 09 2018
revised: 20 12 2018
accepted: 04 01 2019
pubmed: 22 1 2019
medline: 22 3 2019
entrez: 22 1 2019
Statut: ppublish

Résumé

Purine nucleotides such as ATP and ADP are important extracellular signaling molecules in almost all tissues activating various subtypes of purinoreceptors. In the brain, the P2Y

Identifiants

DOI: 10.1016/j.ejmech.2019.01.006 PMID: 30665144
pubmed: 30665144
pii: S0223-5234(19)30006-6
doi: 10.1016/j.ejmech.2019.01.006
pii:
doi:

Substances chimiques

Fluorine Radioisotopes 0
Phenylurea Compounds 0
Radiopharmaceuticals 0
Receptors, Purinergic P2Y1 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

142-159

Informations de copyright

Copyright © 2019 Elsevier Masson SAS. All rights reserved.

Auteurs

Rareş-Petru Moldovan (RP)

Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Permoserstraße 15, 04318, Leipzig, Germany. Electronic address: r.moldovan@hzdr.de.

Barbara Wenzel (B)

Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Permoserstraße 15, 04318, Leipzig, Germany.

Rodrigo Teodoro (R)

Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Permoserstraße 15, 04318, Leipzig, Germany.

Wilma Neumann (W)

Institute of Inorganic Chemistry, Faculty of Chemistry and Mineralogy, Universität Leipzig, 04103, Leipzig, Germany.

Sladjana Dukic-Stefanovic (S)

Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Permoserstraße 15, 04318, Leipzig, Germany.

Werner Kraus (W)

BAM Federal Institute for Materials Research and Testing, Richard-Willstätter-Str. 11, 12489, Berlin, Germany.

Peijing Rong (P)

Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, 100700, Beijing, China.

Winnie Deuther-Conrad (W)

Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Permoserstraße 15, 04318, Leipzig, Germany.

Evamarie Hey-Hawkins (E)

Institute of Inorganic Chemistry, Faculty of Chemistry and Mineralogy, Universität Leipzig, 04103, Leipzig, Germany.

Ute Krügel (U)

Rudolf Boehm Institute of Pharmacology and Toxicology, Medical Faculty, Universität Leipzig, 04107, Leipzig, Germany.

Peter Brust (P)

Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Permoserstraße 15, 04318, Leipzig, Germany.

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Classifications MeSH

questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › Site allostérique › Studies towards the development of a PET...
questionsmedicales.fr › Thérapeutique › Radiothérapie › Radiothérapie de haute énergie › Thérapie par capture de neutrons › Thérapie par capture de neutrons par le bore › Studies towards the development of a PET...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Studies towards the development of a PET...
questionsmedicales.fr › Produits chimiques inorganiques › Isotopes › Radio-isotopes › Radio-isotopes du fluor › Studies towards the development of a PET...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénylurées › Studies towards the development of a PET...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Studies towards the development of a PET...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Indicateurs et réactifs › Radiopharmaceutiques › Studies towards the development of a PET...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs purinergiques › Récepteurs purinergiques P2 › Récepteurs purinergiques P2Y › Récepteurs purinergiques P2Y1 › Studies towards the development of a PET...