Dementia with Lewy bodies: an update and outlook.
Alpha-synuclein
Alzheimer’s disease
Biomarkers
Dementia
Dementia with Lewy bodies
Journal
Molecular neurodegeneration
ISSN: 1750-1326
Titre abrégé: Mol Neurodegener
Pays: England
ID NLM: 101266600
Informations de publication
Date de publication:
21 01 2019
21 01 2019
Historique:
received:
28
11
2018
accepted:
08
01
2019
entrez:
23
1
2019
pubmed:
23
1
2019
medline:
6
7
2019
Statut:
epublish
Résumé
Dementia with Lewy bodies (DLB) is an age-associated neurodegenerative disorder producing progressive cognitive decline that interferes with normal life and daily activities. Neuropathologically, DLB is characterised by the accumulation of aggregated α-synuclein protein in Lewy bodies and Lewy neurites, similar to Parkinson's disease (PD). Extrapyramidal motor features characteristic of PD, are common in DLB patients, but are not essential for the clinical diagnosis of DLB. Since many PD patients develop dementia as disease progresses, there has been controversy about the separation of DLB from PD dementia (PDD) and consensus reports have put forward guidelines to assist clinicians in the identification and management of both syndromes. Here, we present basic concepts and definitions, based on our current understanding, that should guide the community to address open questions that will, hopefully, lead us towards improved diagnosis and novel therapeutic strategies for DLB and other synucleinopathies.
Identifiants
pubmed: 30665447
doi: 10.1186/s13024-019-0306-8
pii: 10.1186/s13024-019-0306-8
pmc: PMC6341685
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
5Subventions
Organisme : Medical Research Council
ID : G1100540
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0900652
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0502157
Pays : United Kingdom
Organisme : Department of Health
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0400074
Pays : United Kingdom
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