The Claudins: From Tight Junctions to Biological Systems.
cell adhesion
claudin
epithelial barrier
tight junction
Journal
Trends in biochemical sciences
ISSN: 0968-0004
Titre abrégé: Trends Biochem Sci
Pays: England
ID NLM: 7610674
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
24
07
2018
revised:
17
09
2018
accepted:
19
09
2018
entrez:
23
1
2019
pubmed:
23
1
2019
medline:
13
4
2019
Statut:
ppublish
Résumé
Claudins are cell-cell adhesion molecules located at the tight junctions (TJs) between cells in epithelial cell sheets. The claudin family in mammals consists of 27 four-transmembrane domain proteins. Claudins are responsible for the paracellular barrier function of TJs, and in some cases confer paracellular channel functions to the paracellular barriers of TJs. Based on recent breakthroughs in the molecular structure of claudins, the hypothetical 'antiparallel double row model' was proposed, which suggests how claudins polymerize in a linear fashion and form TJ strands with paracellular barrier and channel functions. Meanwhile, ongoing studies at the cell and tissue levels are clarifying how the paracellular barrier and/or channel functions of claudin-based TJs, which are both robust and flexible, organize various biological systems.
Identifiants
pubmed: 30665499
pii: S0968-0004(18)30193-2
doi: 10.1016/j.tibs.2018.09.008
pii:
doi:
Substances chimiques
Claudins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
141-152Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.