Anisotropic Material Properties of Wild-Type and Tectb

Animals Anisotropy Biomechanical Phenomena Elasticity Extracellular Matrix Proteins / deficiency Mechanical Phenomena Mice Models, Biological Movement Tectorial Membrane / metabolism Viscosity

Journal

Biophysical journal
ISSN: 1542-0086
Titre abrégé: Biophys J
Pays: United States
ID NLM: 0370626

Informations de publication

Date de publication:
05 02 2019
Historique:
received: 19 10 2018
revised: 28 11 2018
accepted: 28 12 2018
pubmed: 23 1 2019
medline: 21 1 2020
entrez: 23 1 2019
Statut: ppublish

Résumé

The tectorial membrane (TM) is an extracellular matrix that is directly coupled with the mechanoelectrical receptors responsible for sensory transduction and amplification. As such, the TM is often hypothesized to play a key role in the remarkable sensory abilities of the mammalian cochlea. Genetic studies targeting TM proteins have shown that changes in TM structure dramatically affect cochlear function in mice. Precise information about the mechanical properties of the TMs of wild-type and mutant mice at audio frequencies is required to elucidate the role of the TM and to understand how these genetic mutations affect cochlear mechanics. In this study, images of isolated TM segments are used to determine both the radial and longitudinal motions of the TM in response to a harmonic radial excitation. The resulting longitudinally propagating radial displacement and highly spatially dependent longitudinal displacement are modeled using finite-element models that take into account the anisotropy and finite dimensions of TMs. An automated, least-square fitting algorithm is used to find the anisotropic material properties of wild-type and Tectb

Identifiants

DOI: 10.1016/j.bpj.2018.12.019 PMID: 30665694 PMC: PMC6369431
pubmed: 30665694
pii: S0006-3495(19)30001-3
doi: 10.1016/j.bpj.2018.12.019
pmc: PMC6369431
pii:
doi:

Substances chimiques

Extracellular Matrix Proteins 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

573-585

Subventions

Organisme : NIDCD NIH HHS
ID : R01 DC000238
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC016114
Pays : United States
Organisme : NIDCD NIH HHS
ID : R56 DC016114
Pays : United States

Informations de copyright

Copyright © 2019 Biophysical Society. Published by Elsevier Inc. All rights reserved.

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Auteurs

Charlsie Lemons (C)

G.W.W. School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia.

Jonathan B Sellon (JB)

Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts.

Elisa Boatti (E)

G.W.W. School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia.

Daniel Filizzola (D)

Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts.

Dennis M Freeman (DM)

Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts.

Julien Meaud (J)

G.W.W. School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia; Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia. Electronic address: julien.meaud@me.gatech.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Anisotropic Material Properties of Wild-Type and Tectb
questionsmedicales.fr › Phénomènes chimiques › Anisotropie › Anisotropic Material Properties of Wild-Type and Tectb
questionsmedicales.fr › Phénomènes physiques › Phénomènes mécaniques › Phénomènes biomécaniques › Anisotropic Material Properties of Wild-Type and Tectb
questionsmedicales.fr › Phénomènes physiques › Phénomènes mécaniques › Élasticité › Anisotropic Material Properties of Wild-Type and Tectb
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Scléroprotéines › Protéines de la matrice extracellulaire › Anisotropic Material Properties of Wild-Type and Tectb
questionsmedicales.fr › Phénomènes physiques › Phénomènes mécaniques › Anisotropic Material Properties of Wild-Type and Tectb
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Anisotropic Material Properties of Wild-Type and Tectb
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Anisotropic Material Properties of Wild-Type and Tectb
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Mouvement › Anisotropic Material Properties of Wild-Type and Tectb
questionsmedicales.fr › Organes des sens › Oreille › Oreille interne › Cochlée › Conduit cochléaire › Membrane tectoriale › Anisotropic Material Properties of Wild-Type and Tectb
questionsmedicales.fr › Phénomènes chimiques › Viscosité › Anisotropic Material Properties of Wild-Type and Tectb