Alterations on growth and cell organization of Giardia intestinalis trophozoites after treatment with KH-TFMDI, a novel class III histone deacetylase inhibitor.

Antiprotozoal Agents / pharmacology Caco-2 Cells Cytokinesis / drug effects Giardia lamblia / cytology Histone Deacetylase Inhibitors / pharmacology Humans Inhibitory Concentration 50 Microscopy Microscopy, Electron Parasitic Sensitivity Tests Trophozoites / cytology
Automated quantitative fluorescence microscopy Cell death Class III NAD+-dependent histone deacetylases inhibitor Electron microscopy Giardia intestinalis Proliferation

Journal

International journal of medical microbiology : IJMM
ISSN: 1618-0607
Titre abrégé: Int J Med Microbiol
Pays: Germany
ID NLM: 100898849

Informations de publication

Date de publication:
Mar 2019
Historique:
received: 01 03 2018
revised: 30 12 2018
accepted: 14 01 2019
pubmed: 23 1 2019
medline: 14 6 2019
entrez: 23 1 2019
Statut: ppublish

Résumé

Giardia trophozoites have developed resistance mechanisms to currently available compounds, leading to treatment failures. In this context, the development of new additional agents is mandatory. Sirtuins, which are class III NAD

Identifiants

DOI: 10.1016/j.ijmm.2019.01.002 PMID: 30665874
pubmed: 30665874
pii: S1438-4221(18)30103-6
doi: 10.1016/j.ijmm.2019.01.002
pii:
doi:

Substances chimiques

Antiprotozoal Agents 0
Histone Deacetylase Inhibitors 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

130-142

Informations de copyright

Copyright © 2019. Published by Elsevier GmbH.

Auteurs

Ana Paula R Gadelha (APR)

Diretoria de Metrologia Aplicada a Ciências da Vida, Instituto Nacional de Metrologia, Qualidade e Tecnologia, Rio de Janeiro, RJ, Brazil.

Bárbara Bravim (B)

Diretoria de Metrologia Aplicada a Ciências da Vida, Instituto Nacional de Metrologia, Qualidade e Tecnologia, Rio de Janeiro, RJ, Brazil.

Juliana Vidal (J)

Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

Lissa Catherine Reignault (LC)

Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

Bruno Cosme (B)

Diretoria de Metrologia Aplicada a Ciências da Vida, Instituto Nacional de Metrologia, Qualidade e Tecnologia, Rio de Janeiro, RJ, Brazil.

Kilian Huber (K)

Department of Pharmacy, Center for Drug Research, Ludwig-Maximilians-University of Munich, Munich, Germany; Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Franz Bracher (F)

Department of Pharmacy, Center for Drug Research, Ludwig-Maximilians-University of Munich, Munich, Germany.

Wanderley de Souza (W)

Diretoria de Metrologia Aplicada a Ciências da Vida, Instituto Nacional de Metrologia, Qualidade e Tecnologia, Rio de Janeiro, RJ, Brazil; Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil; Instituto Nacional de Ciência e Tecnologia em Biologia Estrutural e Bioimagens e Centro Nacional de Biologia Estrutural e Bioimagens, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil. Electronic address: wsouza@biof.ufrj.br.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiparasitaires › Antiprotozoaires › Alterations on growth and cell organization of...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules Caco-2 › Alterations on growth and cell organization of...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Cycle cellulaire › Cytocinèse › Alterations on growth and cell organization of...
questionsmedicales.fr › Eucaryotes › Diplomonades › Giardia › Giardia lamblia › Alterations on growth and cell organization of...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de désacétylase d'histone › Alterations on growth and cell organization of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Alterations on growth and cell organization of...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Concentration inhibitrice 50 › Alterations on growth and cell organization of...
questionsmedicales.fr › Disciplines des sciences naturelles › Physique › Microscopie › Alterations on growth and cell organization of...
questionsmedicales.fr › Techniques d'investigation › Microscopie électronique › Alterations on growth and cell organization of...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité parasitaire › Alterations on growth and cell organization of...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Morphogenèse › Métamorphose biologique › Étapes du cycle de vie › Trophozoïtes › Alterations on growth and cell organization of...